Bittersweet Effects of Stevia Uncovered

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Summary: The natural sweetener Stevia disrupts communication between different bacteria in the gut.Source: Ben-Gurion University of the NegevAccording to a new study by Ben-Gurion University of...

The Power of Touch: How Physical Contact Can Reshape the Clinical Exam ─ Part...

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This is Part 2 of a 2-part series related to the power of touch in the clinical medical environment. In Part 1, we review the history and...

Exercise Can Help Older Adults Retain Their Memories

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Summary: Regular exercise may help reduce declines in episodic memory for older adults.Source: University of PittsburghWe all know exercise is good for us, but that still...

Predictors of α-Synucleinopathies in Isolated Rapid Eye Movement Sleep Behavior Disorder

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Reliable biomarkers may have an important role in predicting conversion to clinically manifest α-synucleinopathies in patients with isolated rapid eye movement sleep behavior disorder (RBD), and...

Brain structures and networks responsible for stimulation‐induced memory flashbacks during forniceal deep brain stimulation...

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Congratulations to Drs. Wissam Deeb, Leonardo Almeida, Kelly D. Foote  and Michael S. Okun on the publication of “Brain structures and networks responsible for stimulation‐induced memory...

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple...

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Multiple system atrophy (MSA) is an insidious middle age-onset neurodegenerative disease that clinically presents with variable degrees of parkinsonism and cerebellar ataxia. The pathological hallmark of...

Do you have Brain Inflammation? How to know and what to do

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Do you have any of the symptoms of brain inflammation, also called neuroinflammation, listed below? Brain inflammation doesn’t hurt like an inflamed ankle would. Instead it...

A Placebo‐Controlled Trial of Rasagiline » Department of Neurology » College of Medicine »...

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Congratulations Drs. David J. Arpin, Trina Mitchell, Winston T. Chu,Hanzhi Gao MS, Christopher W. Hess, Irene A. Malaty, Nikolaus R. McFarland, Catherine C. Price, Aparna Wagle...

Special programs this holiday season! » Department of Neurology » College of Medicine »...

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Upcoming programs and events Support GroupsAlzheimer’s Association support groups, conducted by trained facilitators, are a safe place for you to share stories and discuss challenges and possible...

The 52 variants of CMT… and their practical checklists – The Neurology Lounge

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Jean-Marie Charcot, Pierre Marie, and Howard Henry Tooth will be confounded to see what has become of the disease they described hundreds of years ago. Charcot-Marie...

FDA Committees Vote on Novel Therapy for Schizophrenia, Bipolar I Disorder

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The Food and Drug Administration (FDA)’s Psychopharmacologic Drug Advisory Committee and the Drug Safety and Risk Management Advisory Committee jointly voted on ALKS 3831 (olanzapine/samidorphan; Alkermes),...

The Glymphatic System: Importance of Sleep for Clearance of Brain Protein Waste

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The glymphatic system, which is most active during sleep, clears the brain of protein waste products, and degradation of this system over time may be linked...

Cognitive Fatigue and Circadian Cortisol Regulation in Multiple Sclerosis

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Cortisol levels are increased in patients with multiple sclerosis (MS) compared with healthy controls, with slightly higher levels among those with MS without than those with...

Long-Term Outcomes of New Onset Super Refractory Status Epilepticus

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Findings from a case series suggest that the majority of patients with new-onset refractory status epilepticus (NORSE) had the more severe new-onset super refractory status epilepticus...

Multi-Strain Probiotic Reduces Constipation in Parkinson Disease

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A multi-strain probiotic consisting of 8 different commercially available bacterial strains reduced constipation in patients with Parkinson Disease (PD), according to study results published in Neurology. Constipation...

FDA Approves Shorter Infusion Time for MS Drug Ocrevus

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The Food and Drug Administration (FDA) has approved the supplemental Biologics License Application (sBLA) for a shorter 2-hour infusion time for Ocrevus® (ocrelizumab; Genentech) for patients...

Shared Underlying Pathways Found for Fatigue and Depression in MS

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Proinflammatory cytokines, tryptophan catabolites, and the gut-brain axis may have key roles in the mechanisms underlying chronic fatigue and symptoms associated with major depressive disorder (MDD)...

COVID-19 Emerging as a Multi-Organ Disease Requiring Multidisciplinary Care

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It is now evident that COVID-19 is not simply an illness of the pulmonary system, but a disease that can have a long-lasting impact on organ...

ACIP Meets to Discuss Janssen COVID-19 Vaccine; Pause on Use Still in Place

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The Centers for Disease Control and Prevention (CDC)’s Advisory Committee on Immunization Practices (ACIP) met on April 14, 2021 to discuss the recent cases of cerebral...

Unmedicated, Untreated Brain Illness Is Likely in Mass Shooters

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Summary: A new analysis of medical evidence of domestic mass shooters in the US reveals the majority of those who commit mass shootings have underlying and...

Stem Cell-Derived Neurons Provide Clues Into Parkinson Disease

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Human midbrain dopamine neurons transplanted into the nigra were able to be specifically projected to the dorsal striatum. These and other findings in a recent study...

Details Behind the Body’s Response to Stress Revealed

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Summary: Study reveals how key proteins regulate the brain’s response to stress in the hippocampus.Source: McLean HospitalThe biological mechanisms behind stress-related psychiatric conditions, including major depressive...

Resilience Is Dynamic, Not a Static Character Trait

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Summary: Resilience fluctuates because it encompasses the way individuals respond to a variety of circumstances over time.Source: North Carolina State UniversityA new study finds that resilience...

FDA Authorizes COVID-19 Test That Provides Rapid Results at Home

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The Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to Lucira Health for its at-home molecular test intended to detect severe acute...

Case Study: Teenage Patient With COVID-19 Experiences Severe Encephalopathy

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A recently published case study described a case of severe encephalopathy associated with coronavirus disease 2019 (COVID-19) in a pediatric patient who developed clinical features characteristic...

Expert Consensus Statement: Determining Brain Death/Death by Neurologic Criteria

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Experts in brain death/death by neurologic criteria (BD/DNC) have convened to publish a consensus statement on global recommendations for determining brain death/death (BD/DNC) by neurologic criteria,...

Vimpat Approved for Primary Generalized Tonic-Clonic Seizures

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The Food and Drug Administration (FDA) has approved Vimpat® (lacosamide; UCB) as adjunctive therapy in the treatment of primary generalized tonic-clonic seizures in patients 4 years of...

Dexmedetomidine Oral Film Under Review for Agitation With Schizophrenia, Bipolar Disorder

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The Food and Drug Administration (FDA) has accepted for filing the New Drug Application (NDA) for BXCL501 (dexmedetomidine) for the acute treatment of agitation associated with...

40 very practical and handy neurology checklists

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Neurochecklists now contains >3,300 checklists on all aspects of neurology. https://pixabay.com/en/brain-anatomy-neurology-medical-1132229/ Many checklists come to the rescue only to fill a knowledge gap. By Samurai Gandhi – Own work,...

Ophthalmologists Vital in Mitigating Systemic Risks for Patients With Diabetic Retinopathy

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Ophthalmologists play an essential role in mitigating cardiovascular and cerebrovascular risks associated with moderate to severe nonproliferative and proliferative diabetic retinopathy, according to research published in...

Is Neuromarketing Next for Tourism?

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In a previous blog post, we explored how one of the most successful EEG departments in the nation borrows customer satisfaction tips from the hospitality industry.But,...

Meningeal Lymphatic Drainage May Help Improve Alzheimer Disease Outcomes

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Modulation of meningeal lymphatic function may positively influence the outcome of immunotherapy for Alzheimer disease (AD), according to a recent study. Passive immunotherapy is emerging as...

Lecanemab Gets Breakthrough Tx Status for Alzheimer Disease

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Topics » Alzheimer's Disease and Dementia

Maternal Use of Anti-Seizure Drugs, Risk of Autism and ADHD in Offspring

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Maternal use of valproic acid during pregnancy may increase the risk for autism spectrum disorders (ASD) and attention-deficit and hyperactivity disorder (ADHD) in children, while lamotrigine...

Remote Ischemic Post-Conditioning With IVT May Improve Acute Ischemic Stroke Recovery

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Repeated remote ischemic post-conditioning (RIPC) combined with intravenous thrombolysis (IVT) can promote nerve function recovery and improve prognosis in patients with acute ischemic stroke, according to...

Apitegromab Fast Tracked for Spinal Muscular Atrophy

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The Food and Drug Administration (FDA) has granted Fast Track designation to apitegromab for the treatment of patients with spinal muscular atrophy (SMA). Apitegromab is a selective...

T25FW, 9HPT Are More Reliable Clinical Outcome Measures for Secondary Progressive MS

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Timed 25 foot walk (T25FW) and 9-hole peg test (9HPT) may be more reliable clinical outcomes measures in patients with secondary progressive multiple sclerosis (SPMS), compared...

Patients with MS and Depression During Pregnancy Have Prolonged Depressive Symptoms

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Women with multiple sclerosis (MS) who experience depression onset during pregnancy had more prolonged depressive symptoms, often lasting into the postpartum period, according to an editorial...

5 Dietary Factors Affecting Glaucoma Risk

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January is National Glaucoma Awareness Month. As glaucoma is insidious, and it cannot be cured and its effects cannot be reversed, ophthalmologists are well positioned to...

Caring for Patients With Duchenne Muscular Dystrophy During COVID-19 Pandemic

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The coronavirus disease 2019 (COVID-19) pandemic resulted in widespread disruptions in care for patients with ongoing medical needs. To reduce the risk of virus exposure, many...

Researchers Look to Building Better Prediction Model for Episodic Migraine Attacks

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A multivariable predictive model including self-prediction and common migraine trigger factors was only slightly better than random for predicting episodic migraine attacks, suggesting that more work...

A Conversation About Racial Disparities in Health Care With Dr Scharles Konadu

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A Conversation About Racial Inequities in Health Care With Dr Scharles Konadu Scharles Konadu, MD, is a member of the American Board of Internal Medicine’s Gastroenterology Specialty...

Addressing Sleep Disturbances of Parkinson Disease

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Among the various nonmotor symptoms affecting patients with Parkinson disease (PD), sleep disturbances are estimated to affect 40% to 90% of this population, and a study...

Complying With HIPAA When Using Social Media

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Posting information online about a patient’s diagnosis is a growing conundrum for those policing the privacy and security rules outlined in HIPAA. In 2018, a pediatric...

Pfizer, BioNTech COVID-19 Vaccine Gets EUA; First Doses Shipped

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The Food and Drug Administration (FDA) has granted Emergency Use Authorization (EUA) to Pfizer and BioNTech’s mRNA vaccine, BNT162b2, for active immunization to prevent coronavirus disease...

The 7 most hazardous occupations to the nervous system – The Neurology Lounge

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A critical part of history taking in medicine is establishing the occupation of the patient. This is because occupational activities and work place exposures are often...

Increased Stroke Risk in Younger Adults During the Convalescent Phase of COVID-19

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Younger adults with asymptomatic or minimally symptomatic COVID-19 are at an increased risk for acute ischemic stroke (AIS) during the convalescent phase of the infection, according...

Provider Confusion Often the Cause of Patient Access Rights Violations

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Significant changes are occurring in the enforcement of patients’ access rights to their health information in a reasonable timeline. On February 12, 2021, the Office for...

Late-Onset Epilepsy Associated With Increased Risk for Subsequent Stroke

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People who are diagnosed with late-onset epilepsy (LOE) at age 30 years or older have a significantly increased risk for future stroke, a study in Epilepsy...

Our Attention Is Captured by Eye-Glance

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Summary: When people make eye contact with another person, their attention is immediately solicited and this causes a distortion in temporal perception. However, the shift in...

Technology Has Broken Healthcare Barriers During the COVID-19 Pandemic

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COVID-19 has prompted clinicians to change how they deliver care and to reallocate resources toward the most urgent needs on a global scale.1 Patients with diseases...

Genetic Link to Molecular Events That Precede Symptoms in Alzheimer’s Disease Found

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Summary: Researchers have identified a molecular mechanism that disrupts the flow of enzymes in axons, results in the accumulation of amyloid plaques.Source: Tufts UniversityResearchers at Tufts...

New Case Definition Proposed for Acute Fulminant Cerebral Edema in Children

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Study researchers proposed a case definition for acute fulminant cerebral edema (AFCE) based on a clinical profile of patients from the California Encephalitis Project (CEP), according...

Clinical Characteristics, MRI Markers Predict Worsening Cognition Over 10 Years in MS

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Baseline age, disability, whole brain volume (WBV), and T2 lesion volume were significant predictors of long-term worsening information processing speed (IPS) in patients with multiple sclerosis...

Preeclampsia May Be a Risk Factor for Later-Life Stroke

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After adjusting for time-varying covariates, preeclampsia may be an independent risk factor for later-life stroke in women who have had 1 or more pregnancies, according to...

Commentary: Neurologists on Palliative Care Communication

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Among the most powerful instruments of healing are patients’ relationships with their doctors or clinicians. Feeling seen and valued by the clinicians they trust helps patients...

Misperception of Sleep Quality Is Common in Patients With Insomnia

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People with insomnia frequently misperceive how much and how well they sleep each night, according to a study in the Journal of Clinical Sleep Medicine. Data is...

The Role of Renin-Angiotensin System in the Pathophysiology of Migraine

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While it does not influence migraine severity, the renin-angiotensin system (RAS) has an important role in the pathophysiology of migraine. Serum levels of angiotensin converting enzyme...

Fluid Therapy Following Traumatic Brain Injury

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There are substantial practice variations in fluid management in patients with traumatic brain injury in the intensive care unit (ICU), with a new study published in...

Cerebrovascular Events in Hematological Diseases

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Although hematological diseases generally represent a relatively uncommon cause of stroke, an elevated risk of cerebrovascular complications has been observed in patients with these conditions.1 In...

Significant Negative Association Between Educational Attainment and Depression Among Children

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Lower educational attainment among children and adolescents was associated with symptoms of depression. These findings, from a systematic review and meta-analysis, were published in the Journal...

Propranolol Reduces Temporomandibular Disorder Pain in People With Migraine

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Propranolol is more effective in reducing temporomandibular disorder (TMD) pain in people with migraine compared with people without migraine, according to research published in Cephalalgia. Building on...

A First Look at How the Psychedelic Salvinorin A Works in the Brain

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Summary: As with other psychedelics, salvinorin A increased activity across the brain. However, salvinorin A use resulted in more random and disconnected signaling in the default...

Screening for Obstructive Sleep Apnea in Patients With MS

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The STOP-Bang Questionnaire may be an effective tool in screening patients with multiple sclerosis for moderate to severe obstructive sleep apnea (OSA), although the questionnaire may...

Improvements in Depression Linked to Improvements in Fatigue, Pain in MS

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Reducing depressive symptoms early may result in better improvements in functional impairment related to fatigue and pain in patients with multiple sclerosis (MS), according to study...

New Guidelines for the Management of Lyme Disease

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The Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology collaborated to provide new clinical practice guidelines for the prevention, diagnosis,...

Early Coagulopathy Increases Mortality Risk in Children With TBI

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Early coagulopathy increases the risk of mortality and poor functional outcomes in both adults and children with traumatic brain injury (TBI), according to study results published...

Teen depression explodes along with smart phone use

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Although depression continues to rise among the population as a whole, it is rising most dramatically among teens, and smart phones may be largely to blame....

Systematic Pain Review Sets the Stage for a Gold Standard of Patient Care

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The lack of a gold standard to compare pain mechanism categories (PMCs) in the pain management field represents an urgent research need, and expert consensus according...

Severe White Matter Lesions Predict Poor Functional Outcomes After Acute Ischemic Stroke

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An association between ventricular function and vascular loading and outcomes was observed in patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing pulmonary thromboendarterectomy (PTE), according to...

Galcanezumab May Improve Quality of Life in Episodic and Chronic Migraine

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Migraine substantially impacts patients’ daily activity and quality of life (QoL), suggesting the assessments of these domains should be incorporated into treatment approaches as well as...

Steroids Not Indicated for Every Patient with MS-Related Optic Neuritis

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Despite its side effects, intravenous methylprednisolone is still used by many ophthalmologists and neurologists to treat multiple sclerosis (MS)-related demyelinating optic neuritis, according to researchers. However,...

Genetic Variants Linked to Lacunar Stroke and White Matter Hyperintensity

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A dozen loci were found to be associated with lacunar stroke during a pooled genome-wide association study (GWAS), according to study results published in The Lancet...

Predicting Neurologic Recovery After Cardiac Arrest With MRI Data

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Brain magnetic resonance imaging (MRI) data may improve the prediction of neurologic recovery after cardiac arrest (CA), according to study findings published in Neurology. Study researchers in...

Origin of a Deadly Brain Cancer Identified

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Summary: Researchers have identified a cancer-causing mutation in the PDGFRA gene that drives cell mutation and growth when activated. The findings have implications for the treatment...

Digital Health Information Divide Puts Many Older Adults at a Disadvantage

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Many individuals aged 60 years or older lack access to digital health information (DHI), and this lack of access varies widely by race, ethnicity, and income,...

Later High School Start Time Linked to Decreased Adolescent Migraine Frequency

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High school students with migraine report a lower headache frequency if their school starts at 8:30 am or later, a starting time recommended by the American...

P-Glycoprotein Removes Alzheimer’s-Associated Toxin From the Brain

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Summary: P-glycoprotein, a critical toxin pump in the body, has the ability to remove amyloid plaques from the brain. Researchers say increasing P-gp in the blood-brain...

Pregnancy and Delivery Outcomes in Women with Charcot-Marie Tooth Disease

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Among women with a diagnosis of Charcot-Marie-Tooth (CMT), the course of pregnancy and delivery outcomes were not significantly different compared with the general population, according to...

Sleep Disturbance in Adolescence Associated With Opioid Misuse in Adulthood

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Sleep deficiency in adolescence may be an independent risk factor for the development of prescription opioid misuse, according to results of a study published in Sleep....

Childhood TBI Causes Widespread and Persistent White Matter Disruption

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Following moderate to severe traumatic brain injury (msTBI) in children, white matter disruption was widespread, persistent, and impacted by demographic and clinical factors, according to study...

How Social Discrimination Affects the Brain

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It has become clear that racism and other forms of social discrimination have a negative impact on health outcomes. Only recently, though, have scientists begun to...

Certain Sleep Disorders Associated With Lower Gray Matter Volume

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Cortical arousal, a component of sleep apnea, is associated with lower grey matter volume in the left frontal pole, a new study in the Sleep journal...

Patient-Identified Most Bothersome Chronic Migraine Symptom: Promising Clinical Research Endpoint

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Eptinezumab therapy for chronic migraine is associated with more improvement in patient-identified most bothersome symptoms compared with placebo, demonstrating that patient-identified most bothersome symptom is a...

Predicting Epilepsy From Neural Network Models

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Summary: An innovative new model helps predict how damaging conditions in the brain can be triggered by complex dynamics in branching neural networks.Source: SpringerWithin the staggeringly...

Tilavonemab Not Effective in Progressive Supranuclear Palsy

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Among patients with progressive supranuclear palsy (PSP), treatment with tilavonemab did not affect progression of the disorder and the phase 2 study was terminated after a...

Lowest Optimal Cutoffs to Predict Future â-Amyloid Accumulation and Cognitive Decline

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Researchers have identified the lowest optimal cutoff values for detecting â-amyloid (Aâ) accumulation as assessed by positron emission tomography (PET), with these cutoff values offering sufficient...

11 vintage catchy titles from the neurology archives – The Neurology Lounge

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It is always heartwarming when the authors of a research paper, or a case report, go the extra mile to give their article a catchy title....

Specific Brain Region and Circuits Controlling Attention Identified

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Summary: Study identifies a key role locus coeruleus neurons play in attentional control.Source: Picower Institute of Learning and MemoryThe attentional control that organisms need to succeed...

Importance of Antibody Binding Patterns in Inflammatory Demyelinating Diseases

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Differential binding of serum immunoglobulin G (IgG) antibodies to major isoforms of myelin oligodendrocyte glycoprotein (MOG) in inflammatory demyelinating diseases is associated with clear structural differences...

AS03-Adjuvanted Flu Vaccine Increases Narcolepsy Incidence, Clinically Similar to Sporadic Cases

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Immunization with the AS03-adjuvanted H1N1 influenza vaccine was associated with an increased incidence of narcolepsy, but narcolepsy associated with vaccination had similar clinical features as sporadic...

Chronic Migraine and Medication Overuse Headache Impact Patients’ Quality of Life

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In the United States, outpatients with chronic migraine (CM) with medication overuse headache (MOH) experience frequent headaches and have a very high-frequency intake of acute treatments,...

HIPAA Needs to Keep Up With Information Technology

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Major updates with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule are expected in the coming months, and many stakeholders are hoping for some...

Increased Social Media Use Linked to Developing Depression

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Summary: Young adults who spend 300 or more minutes on social media a day are 2.8 times more likely to develop depression within six months than...

Addressing Sleep Disorders in Individuals with Autism Spectrum Disorders

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Individuals with autism spectrum disorder (ASD) often experience disordered sleep — in fact, studies show that between 50% and 83% of individuals with ASD experience insomnia...

Predicting Recovery of Patients With Post-Traumatic Trigeminal Neuropathy

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Subjective well-being may be a contributing factor for neurosensory recovery following post-traumatic trigeminal neuropathy (PTN). These findings from a prospective observational study were published in The...

SARS_CoV_2 Can Infect Neurons and Damage Brain Tissue

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Summary: SARS_CoV_2, the virus responsible for COVID-19, can directly enter the nervous system. The virus can infect the brain, causing alterations in blood vessels and directly...

Tissue Biopsy for Progressive Bilateral Optic Neuropathy Diagnosis: A Case Report

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A case report of a patient presenting with bilateral vision loss led to the diagnosis, on the basis of tissue biopsy, of progressive bilateral optic neuropathy....

Trigeminal Neuralgia: A Rare Facial Pain Condition Comprising 3 Distinct Subtypes

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A narrative review published in Headache found that research into all aspects of trigeminal neuralgia (TN) is needed to streamline accurate diagnosis and treatment success. TN is...

Intense Teen Romances May Predict High Blood Pressure Later in Life

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Summary: Teens who find themselves in intense, controlling relationships, where they are denied healthy external friendships and self-discovery, have a higher risk for high blood pressure...

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