Researchers Uncover New Pathway for Accumulation of Age-Promoting ‘Zombie Cells’

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Summary: Oxidative damage to telomeres can trigger cellular senescence. The findings could lead to the development of new therapeutics for healthy aging and to combat cancers.Source:...

New or Worsening Neurologic Symptoms Post-COVID in Patients With Multiple Sclerosis

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More severe COVID-19 and sequelae were associated with new or worsening neurologic symptoms among over a third of patients with multiple sclerosis (MS). These findings, from...

Robot Nose That Can “Smell” Disease on Your Breath

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Summary: A new robotic system can identify volatile organic compounds associated with diseases by analyzing bodily emissions.Source: Tsinghua University PressScientists are working on diagnostic techniques that...

Can the Gold Coast Criteria for ALS Help Boost Clinical Trial Participation?

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Characterizing patients with amyotrophic lateral sclerosis (ALS) according to the Gold Coast criteria (GCC) may allow for more patients to participate in clinical trials, however, it...

Visual Mental Imagery: A Patient Case Suggests a New Key Brain Network

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Summary: Researchers identified a novel brain network that includes the fronto-parietal networks and fusiform gyrus which helps with the encoding of visual mental imagery.Source: Paris Brain...

The Efficacy of 3 Neuroprotective Drugs

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Fluoxetine, riluzole, and amiloride did not compare favorably with placebo for improving neuropathic pain symptoms in adults with secondary progressive multiple sclerosis (SPMS), according to a...

How the Pandemic and Social Distancing Have Changed Our Perception of Time

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Summary: A new study reveals how the COVID-19 pandemic changed the perception of time for many people. Researchers say people felt time passed more slowly during...

What’s the Cause Behind Symptom Dissatisfaction in Myasthenia Gravis?

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Among patients with generalized myasthenia gravis (gMG), unhappiness with life, including depression, fatigue, disease duration and severity is common, according to study findings published in the...

Supernumerary Virtual Robotic Arms Can Feel Like Part of Our Body

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Summary: Researchers have developed a virtual robotic arm that can be controlled by a person’s feet in a virtual environment to provide an “extra” limb. After...

Coma, Delirium, and Mortality Risk Among Patients Hospitalized With COVID-19

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In patients who have been hospitalized with COVID-19, persistent viral shedding occurs often, which is associated with in-hospital coma, delirium, and increased 6-month mortality, according to...

Let Your Mind Control the Computer

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Summary: New software can perform computerized image editing using only input from electrical activity in the human brain.Source: University of CopenhagenSoon, we won’t need to use...

Violating Patient Confidentiality Is Sometimes Necessary

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Halfway through a hectic clinic afternoon, a patient well-known to you reports as an aside that she has been occasionally using cocaine when she goes out...

Alzheimer’s Disease Affects Most Known Biological Pathways in the Brain

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Summary: Out of 341 known biological pathways, 91% are linked to Alzheimer’s disease.Source: Beth Israel Deaconess Medical CenterNearly 6 million older adults have Alzheimer’s disease in...

Acupuncture Treatment Beneficial for Poststroke Unilateral Spatial Neglect

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The use of acupuncture in patients who have experienced a stroke can promote the rehabilitation of cognitive function, activities of daily living (ADLs), and motor function,...

DAT and TH expression marks human Parkinson’s disease in peripheral immune cells » Department...

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Congratulations to Drs. Okun and Rameriz-Zamora on the publication of “DAT and TH expression marks human Parkinson’s disease in peripheral immune cells,” in the June 7th...

Untangling the APOE4 Gene, the Most Significant Genetic Risk Factor for Alzheimer’s Disease

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Summary: The genetic background around APOE region can modify the Alzheimer’s disease-associated APOE4 risk effects.Source: Boston UniversityAlzheimer’s disease (AD) is a progressive neurodegenerative disorder and the...

Characteristics of Baseline Huntington Disease Based on Age at Onset

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Among patients with late-onset Huntington disease (LoHD), a retrospective, observational study found evidence that cognitive disorders and motor symptoms are at least, in part, related with...

Can Acupuncture Reduce Headaches? – Neuroscience News

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Summary: Researchers report acupuncture may help alleviate symptoms for sufferers of chronic tension headaches.Source: AANAcupuncture may reduce headaches for people who have chronic tension-type headaches, according...

Effect of Weight Training on SDMT Scores in Patients With MS

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There is a slight learning effect based on the Symbol Digit Modalities Test (SDMT) scores of patients with multiple sclerosis (MS) who complete a body weight...

Social Integration and Social Support Predict Health and Well-Being of Individuals With Multiple Sclerosis

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Summary: Social support and social integration help improve overall health and well-being for those with multiple sclerosis.Source: Kessler FoundationResearchers conducted a comprehensive online survey of people...

New Neuropsychiatric Risks Among COVID-19 Patients Tied to Disease Severity

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Neuropsychiatric sequelae after severe COVID-19 was similar to the sequelae following other severe acute respiratory infections (SARIs), according to study findings published in JAMA Psychiatry. Data from...

Who Benefits From Brain Training and Why?

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Summary: People who are competent at “near transfer”, or skilled ability at similar games, are more likely to also have far transfer skills, meaning a greater...

Thinner Ganglion Cell Layers Observed in Patients With Neurological Symptoms Following COVID-19

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Thinner ganglion cell layer thickness (GCLT) may be associated with neurological symptoms following recovery from COVID-19, according to a study published in Clinical Neurology and Neurosurgery.   Researchers...

A systematic review » Department of Neurology » College of Medicine » University of...

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Congratulations to Drs. Okun and Rameriz-Zamora on the publication of “Effects of MAO-B inhibitors on non-motor symptoms and quality of life in Parkinson’s disease: A systematic...

The Benefits of Exercise in a Pill? Science Is Closer to That Goal

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Summary: Researchers have identified a molecule in the blood that is produced during exercise. The molecule, Lac-Phe, can effectively reduce food intake and obesity in mouse...

Can Weight Loss/Lifestyle Intervention Effectively Address OSA?

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Use of an interdisciplinary weight loss and lifestyle intervention in overweight or obese Spanish men with moderate to severe obstructive sleep apnea (OSA) who were receiving...

The Sensations Experienced in Reading Poetry

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Summary: Using neuroscience concepts, researchers evaluate the emotional sensation and analytical representations that occur as we read poetry.Source: Tallinn UniversityIn addition to searching for the meaning...

Motor and Language Deficits Common in Children Evaluated for Autism

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Children suspected of autism spectrum disorder (ASD) should be evaluated for co-occurring motor and structural language deficits, according study findings published in Research in Developmental Disabilities. ASD...

How Problems Are Mapped in the Brain

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Summary: Study explores how the brain utilizes learning by inference by generating cognitive maps.Source: UC DavisBoth humans and other animals are good at learning by inference,...

Co-Use of Alcohol and Cannabis and Its Effect on Mood, Subjective Experience

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The use of cannabis affected mood and subjective experience, alcohol impaired cognition and affected psychomotor performance, and the co-use of cannabis and alcohol was at most,...

Scientists Transplant Human Photoreceptors to Successfully Recover Daylight Perception in Mice

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Summary: Researchers developed a new method for producing high numbers of human photoreceptor cells. The human photoreceptor cells can be transplanted in bulk to partially degenerated...

UF researchers identify blood biomarker that could aid in Parkinson’s diagnosis » McKnight Brain...

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By Michelle Jaffee New research by University of Florida neuroscientists shows there are alterations in the expression of two specific proteins in blood immune cells of patients...

Trade the Chair for Fresh Air: Study Explores Link Between Sitting Time and Cardio...

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Summary: Those who sit for six or more hours a day are at a substantially increased risk for heart disease and early death.Source: Simon Fraser UniversityNew...

Eptinezumab Robustly Prevents Migraine in Patients With Prior Treatment Failures

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Eptinezumab significantly reduced monthly migraine days (MMD) up to week 24 compared with placebo among patients with episodic or chronic migraine who had 2 to 4...

Most Male Suicides in Us Show No Link to Mental Health Issues

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Summary: 60% of male suicide victims have no prior history of documented mental health problems, a new study reports.Source: UCLAA majority of American men who die...

Galcanezumab Reduces Episodic Migraine Days, Improves Patient Quality of Life

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Galcanezumab demonstrated superior prevention against episodic migraine than placebo in a phase 3 placebo-controlled study presented at the 2022 American Headache Society (AHS) Annual Scientific Meeting,...

True Grit: Keeping the Faith, or Willingness to Push Yourself, as You Age

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Summary: Maintaining a growth mindset and belief in yourself as you age helps you succeed at skills you wish to master.Source: NTNUSo you could have become...

Psychotic Symptoms Impact Quality of Life of Nursing Home Residents With Dementia

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Psychotic symptoms in people with dementia in nursing homes are associated with poorer quality of life, according to study findings published in JAMDA. Patients with dementia who...

Negative Schizotypal Traits Predict Reward Motivation Reduction in Effort-Reward Imbalance

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Summary: People who display high schizotypal traits are more likely to perceive effort-reward imbalance. Researchers found a link between effort-reward imbalance and reduced gray matter volume,...

Black Patients With Metastatic Breast Cancer Willing to Consider Clinical Trials

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HealthDay News — Black patients with metastatic breast cancer (MBC) are willing to consider participating in clinical trials, according to a study presented at the annual...

Endocrine-Disrupting Chemical Exposure in Womb Impact Fear, Anxiety Behavior

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Summary: A new rat study exposed to everyday endocrine-altering chemicals, such as BPA during pregnancy, interfered with fetal brain development.Source: The Endocrine SocietyPrenatal exposure to endocrine-disrupting...

T2D Tied to Accelerated Brain Aging, Cognitive Decline

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HealthDay News — Type 2 diabetes mellitus (T2DM) is associated with neurocognitive changes suggestive of accelerated brain aging, according to a study published online May 24...

Latin Dance May Be a Step Toward Better Working Memory for Older Latinos

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Summary: Latinos aged 55 and older who participated in Latin dance classes for eight months showed significant improvement in working memory over their peers who did...

Dual Decline in Memory, Gait Speed Tied to Higher Dementia Risk

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HealthDay News — The combination of decline in both gait speed and memory has the strongest association with dementia risk in older adults, according to a...

Updates in Neurotechnology and Neuromodulation, Volume II » Department of Neurology » College of...

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Congratulations to Drs. Ramirez-Zamora and Okun on the publication of the editorial: “Deep Brain Stimulation Think Tank: Updates in Neurotechnology and Neuromodulation, Volume II,” which was...

Are We Born With a Moral Compass?

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Summary: Study reports young infants can make and act on moral judgments, shedding new light on the origins of human morality.Source: Osaka UniversityFor millennia, philosophers have...

next steps » Department of Neurology » College of Medicine » University of Florida

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Congratulations to Drs. Joshua Wong and Michael Okun on the publication of “Connectomic imaging to predict and prevent cognitive decline after subthalamic DBS: next steps,” in...

An Intriguing Connection Between Diet, Eye Health, and Lifespan

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Summary: A new study of drosophila reveals a link between circadian rhythm, diet, lifespan, and eye health. Unexpectedly, researchers found processes in the fly eye that...

Nabiximols Treatment Effect on Spasticity in Patients With MS

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Treatment with nabiximols in patients with multiple sclerosis (MS) demonstrated a significant, sustained effect on spasticity numeric rating scale (NRS) score and spasm frequency, regardless of...

Adults Sleep Better Together Than They Do Alone

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Summary: Adults who share a bed with their partners sleep better than those who sleep alone. Researchers found bed-sharing was associated with a lower risk of...

Safety, Efficacy of Dimethyl Fumarate for Multiple Sclerosis in Minority Groups

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Dimethyl fumarate (DMF) is a safe and effective treatment for Black/African American and Hispanic/Latino patients with multiple sclerosis (MS), according to a real-world evidence study presented...

Have Girls Been Left Behind During the Pandemic?

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Summary: The COVID-19 pandemic and lockdowns affected girls’ mental health more than boys’, researchers report. Girls’ emotional and behavioral difficulties increased by 1.6% compared to boys,...

Neurofilament Light Chain Levels May Predict Multiple Sclerosis Disease Activity

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Baseline neurofilament light chain (NfL) levels may be a biomarker of future lesion activity observed during magnetic resonance imaging (MRI) and relapse risk among patients with...

New Study To Evaluate Psilocybin’s Therapeutic Potential On Autistic Adults

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Summary: A new study will explore how psilocybin affects different networks and serotonin function in the brains of autistic adults.Source: King’s College LondonThe study will explore...

Can It Help Treat Depressive Symptoms?

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Transcranial magnetic stimulation (TMS) may effectively treat depressive symptoms in people with multiple sclerosis (MS), according to preliminary data presented at the 2022 Annual Meeting of...

Researchers Make a Novel Discovery in Age-Related Macular Degeneration

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Summary: Treatment with Humanin G reduced protein levels of inflammation markers that become elevated in age-related macular degeneration.Source: Impact JournalsInflammatory processes drive the progression of age-related macular...

Safety, Efficacy of Cladribine for Relapsing-Remitting MS: Real-World Data

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The use of oral cladribine is a safe and effective treatment for relapsing-remitting multiple sclerosis (RRMS), according real-world evidence presented at the Annual Meeting of the...

Study Confirms Benefit of Supplements for Slowing Age-Related Macular Degeneration

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Summary: The AREDS2 dietary supplement that substitutes antioxidants lutein and zeaxanthin for beta-carotene reduces the risk of age-related macular degeneration progression, a new study reveals.Source: NIHThe Age-Related...

Ultra-High Dose Vitamin B12 Slows Progression of ALS

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An ultrahigh dose of methylcobalamin safely and effectively slowed the progression of functional decline in patients with early-stage amyotrophic lateral sclerosis (ALS) with a moderate progression...

Newly Discovered Brain Cell Sheds Light on the Formation of Memories

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Summary: Researchers discovered novel neurons in the hippocampus that become active when the brain creates new memories.Source: Aarhus UniversityResearchers have long known that memory is represented...

Adults in 50s and Seizure Outcomes Following Resective Epilepsy Surgery

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Age 50 years and older should not be considered an exclusion criterion for resective epilepsy surgery (RES) in patients with drug-resistant temporal lobe epilepsy (TLE), according...

Genetic Sex Determines the Way Your Muscle “Talks” to Other Tissues in Your Body

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Summary: Sex-specific circuits in muscles signal to other tissues and organs, processing muscle impact differently in males and females.Source: UC IrvineA new University of California, Irvine-led...

Preterm Exposure to Corticosteroids and Risk for Mental or Behavioral Disorders

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Exposure to antenatal corticosteroids is associated with a reduced risk for neurodevelopmental impairment in children with extremely preterm birth but an increased risk for adverse neurocognitive...

Acute Stress May Be Detrimental to Fighting Off COVID-19 and Flu

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Summary: Study reveals how acute stress influences the brain’s control over immune response, impacting recovery from COVID-19 and influenza.Source: Mount Sinai HospitalAcute stress can be detrimental...

Neuromuscular Electrical Stimulation Therapy Improves Knee OA Symptoms

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A 12-week neuromuscular electric stimulation (NMES) home exercise program was shown to decrease pain and stiffness and improve functional capacity and strength in patients with knee...

New Insights Into the Complexity of the Brain

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Summary: A new computational model of the C. elegans neural activity serves to unmask the roles of different neurons.Source: CSHA recent study out of the Complexity...

Coping With School Shootings – Neuroscience News

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Summary: In the wake of the school shooting in Uvalde, psychologists report on the best way to address such tragedies to young children and explore how...

CBT, Contingency Management for Smoking Cessation in Adults With Obesity

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Among adults with a body mass index (BMI) of at least 25 who want to quit smoking but worry about weight gain after quitting, offering interventions...

On Your Back, Side, or Face-Down? How We Sleep May Trigger or Protect Our...

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Summary: A new mouse study reveals our sleep position may influence the glymphatic system and could increase the risk of developing ALS or other neurodegenerative diseases.Source:...

Impact of Physical Activity Levels on Processing Speed in MS

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Moderate-to-vigorous physical activity is associated with cognitive processing speed in patients with multiple sclerosis (MS), according to study findings published in Multiple Sclerosis and Related Disorders. Patients...

A Biomarker That Can Diagnose Parkinson’s Disease

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Summary: Researchers have developed a new biomarker that will enable a rapid and inexpensive test for Parkinson’s disease.Source: Kobe UniversityResearchers at Kobe University and Hiroshima University...

How Common Are Neuromuscular Disorders Following COVID-19 Vaccination?

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Within weeks of vaccination for COVID-19, the development of neuromuscular disorders such as Guillain-Barré syndrome (GBS) and peripheral neuropathies may develop due to a close temporal...

Seven Healthy Habits Linked to Lower Risk of Dementia in Those With Genetic Risk

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Summary: From keeping active and eating a healthy diet to controlling cholesterol and reducing sugar intake, researchers report on seven simple lifestyle changes older adults with...

The Effects of Mental Practice on Mobility in Early Subacute Poststroke Phase

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Among patients in the early subacute poststroke phase, the use of mental practice was not associated with improvements in mobility, muscular strength, quality of life (QoL),...

Research Does Not Support the Adage “Boys Will Be Boys”

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Summary: Study reveals there are not that many “girlish girls” or “boyish boys.”Source: University of HelsinkiA research article published in the European Journal of Personality demonstrates that girls...

The Risk for Guillain-Barré Syndrome Following J&J COVID-19 Vaccination

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The incidence of Guillain-Barré syndrome (GBS) was elevated following vaccination with the Janssen COVID-19 vaccine Ad.26.COV2.5, according to study findings published in JAMA Network Open. In the...

A Subtle Genetic Change Gives New Clues About Epilepsy

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Summary: A new study sheds light on the biological mechanism behind some genetic forms of epilepsy.Source: Linköping UniversitySometimes, even the alteration of a single nucleotide in...

ANN Model Predicts Post-MVD Pain Among Patients With Trigeminal Neuralgia

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An artificial neural network (ANN) model could predict long-term pain prognosis among patients with trigeminal neuralgia (TN) who underwent microvascular decompression (MVD), according to study findings...

Robotic Surgery Is Safer and Improves Patient Recovery Time

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Summary: Robotic surgery for bladder removal decreased recovery time and hospital stay duration for patients, researchers report.Source: UCLRobot-assisted surgery used to perform bladder cancer removal enables...

Serum Urate Levels in Gout and Risk for Parkinson Disease in Older Adults

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Elevated serum urate levels in gout provide neuroprotective effects, reducing the risk for Parkinson disease (PD) in both men and women, especially over the age of...

Social Isolation in Childhood Is Associated With ADHD Symptoms and Loneliness in Young Adulthood

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Summary: Young children who experience social isolation are at risk of being diagnosed with ADHD and face loneliness as adults, a new study reports.Source: King’s College...

Dementia Risk in Patients With Atrial Fibrillation Tied to Diabetes, Stroke

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An increased risk for dementia has been reported among patients with atrial fibrillation (AF) associated with diabetes and stroke, according to study findings published in The...

Novel Preclinical Drug Could Have Potential to Combat Depression, Brain Injury, and Cognitive Disorders

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Summary: A preclinical drug that inhibits the kinase enzyme Cdk5 may have the potential to treat depression, brain injuries, and disorders associated with cognitive impairment.Source: University...

Risk Factors, Mechanisms, and Interventions

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Stroke-associated pneumonia (SAP) is a common post-stroke complication that generally occurs within 7 days of stroke onset in approximately one-third of patients with acute stroke.1,2 This...

Long-term Outcomes for Mood, Anxiety and Apathy in Dystonia with Bilateral DBS Surgery (P1-1.Virtual)...

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Congratulations to Emma Leone, Varun Jain, Rohini Kumar, Nivedita Jha, Lina Ly, Charles Jacobson, Kelly Foote, Michael Okun, and on the publication of “Long-term Outcomes for Mood, Anxiety and Apathy in Dystonia...

How the Brain Changes During Depression Treatment

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Summary: A new study reveals the mechanisms behind repetitive transcranial magnetic stimulation’s effect on the brain in the treatment of depression.Source: University of British ColumbiaFor the...

Dapsone for Alzheimer Disease Exacerbation as a Preventive Therapeutic Option

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The use of dapsone (4,4 ′-diaminodiphenyl sulfone, ) as a therapeutic option for the prevention of Alzheimer disease (AD) exacerbation has shown promise, according to study...

IProgramming Time and the Use of a Visualization Tool for DBS Programming of a...

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Congratulations to Drs. Michael Okun and Kelly Foote on the publication of “Programming Time and the Use of a Visualization Tool for DBS Programming of a...

Both Nature and Nurture Contribute to Signatures of Socioeconomic Status in the Brain

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Summary: Both genetics and environmental factors contribute to socioeconomic status’ impact in an interplay with effects that spans several areas of the brain.Source: University of PennsylvaniaYour...

Tailored Cognitive Therapy Helps Black Women With Insomnia Symptoms

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The Sleep Healthy Using the Internet (SHUTi)-Black Women’s Health Study (BWHS) cognitive behavioral therapy for insomnia (CBT-I) was more effective at engaging participants compared with the...

The INTREPID Randomized Controlled Trial (P8-11.002) » Department of Neurology » College of Medicine...

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Congratulations to Drs. Stiep, Rameriz-Zamora and Okun on the publication of “Impulse Control Disorders Following Bilateral Subthalamic Deep Brain Stimulation for Parkinson’s Disease: The INTREPID Randomized...

Binge Drinking Has a Powerful Impact on the Adolescent Brain

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Summary: Adolescent binge drinking has vast functional implications on the developing brain, researchers report. Binge drinking decreases function in areas responsible for sensory, motor, memory, and...

How Sleep Restriction Impacts Cortical Inhibition in Patients With Migraine

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Among individuals with migraine in the period between migraine attacks, the activity of the neurons that selectively offset the action of other neurons (GABAergic cortical inhibition)...

The INTREPID Randomized Controlled Trial (P8-11.001) » Department of Neurology » College of Medicine...

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Congratulations to Drs. Stiep, Rameriz-Zamora and Okun on the publication of “Apathy Following Bilateral Subthalamic Deep Brain Stimulation for Parkinson’s Disease: The INTREPID Randomized Controlled Trial...

If You Stand Like Superman or Wonder Woman, Would You Feel Stronger?

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Summary: A new meta-analysis study reviews the effects of body posture on positive self-perception, reporting a dominant pose or strong upright posture can help people feel,...

Some Plasma Biomarkers for AD Misleading in Black Populations – A Conversation With Susan...

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Three out of 4 serum biomarkers for Alzheimer disease (AD) were inconsistent among Black patients, according to results of a study published in Neurology. Data for this...

Common Fungicide Detected in Pregnant Women and Children

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Summary: Researchers have detected biomarkers for the common fungicide azoxystrobin (AZ) in the urine of pregnant women and children between the ages of 40-84 months. In...

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