Novel Preclinical Drug Could Have Potential to Combat Depression, Brain Injury, and Cognitive Disorders

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Summary: A preclinical drug that inhibits the kinase enzyme Cdk5 may have the potential to treat depression, brain injuries, and disorders associated with cognitive impairment.Source: University...

Risk Factors, Mechanisms, and Interventions

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Stroke-associated pneumonia (SAP) is a common post-stroke complication that generally occurs within 7 days of stroke onset in approximately one-third of patients with acute stroke.1,2 This...

Long-term Outcomes for Mood, Anxiety and Apathy in Dystonia with Bilateral DBS Surgery (P1-1.Virtual)...

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Congratulations to Emma Leone, Varun Jain, Rohini Kumar, Nivedita Jha, Lina Ly, Charles Jacobson, Kelly Foote, Michael Okun, and on the publication of “Long-term Outcomes for Mood, Anxiety and Apathy in Dystonia...

How the Brain Changes During Depression Treatment

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Summary: A new study reveals the mechanisms behind repetitive transcranial magnetic stimulation’s effect on the brain in the treatment of depression.Source: University of British ColumbiaFor the...

Dapsone for Alzheimer Disease Exacerbation as a Preventive Therapeutic Option

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The use of dapsone (4,4 ′-diaminodiphenyl sulfone, ) as a therapeutic option for the prevention of Alzheimer disease (AD) exacerbation has shown promise, according to study...

IProgramming Time and the Use of a Visualization Tool for DBS Programming of a...

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Congratulations to Drs. Michael Okun and Kelly Foote on the publication of “Programming Time and the Use of a Visualization Tool for DBS Programming of a...

Both Nature and Nurture Contribute to Signatures of Socioeconomic Status in the Brain

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Summary: Both genetics and environmental factors contribute to socioeconomic status’ impact in an interplay with effects that spans several areas of the brain.Source: University of PennsylvaniaYour...

Tailored Cognitive Therapy Helps Black Women With Insomnia Symptoms

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The Sleep Healthy Using the Internet (SHUTi)-Black Women’s Health Study (BWHS) cognitive behavioral therapy for insomnia (CBT-I) was more effective at engaging participants compared with the...

The INTREPID Randomized Controlled Trial (P8-11.002) » Department of Neurology » College of Medicine...

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Congratulations to Drs. Stiep, Rameriz-Zamora and Okun on the publication of “Impulse Control Disorders Following Bilateral Subthalamic Deep Brain Stimulation for Parkinson’s Disease: The INTREPID Randomized...

Binge Drinking Has a Powerful Impact on the Adolescent Brain

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Summary: Adolescent binge drinking has vast functional implications on the developing brain, researchers report. Binge drinking decreases function in areas responsible for sensory, motor, memory, and...

How Sleep Restriction Impacts Cortical Inhibition in Patients With Migraine

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Among individuals with migraine in the period between migraine attacks, the activity of the neurons that selectively offset the action of other neurons (GABAergic cortical inhibition)...

The INTREPID Randomized Controlled Trial (P8-11.001) » Department of Neurology » College of Medicine...

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Congratulations to Drs. Stiep, Rameriz-Zamora and Okun on the publication of “Apathy Following Bilateral Subthalamic Deep Brain Stimulation for Parkinson’s Disease: The INTREPID Randomized Controlled Trial...

If You Stand Like Superman or Wonder Woman, Would You Feel Stronger?

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Summary: A new meta-analysis study reviews the effects of body posture on positive self-perception, reporting a dominant pose or strong upright posture can help people feel,...

Some Plasma Biomarkers for AD Misleading in Black Populations – A Conversation With Susan...

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Three out of 4 serum biomarkers for Alzheimer disease (AD) were inconsistent among Black patients, according to results of a study published in Neurology. Data for this...

Common Fungicide Detected in Pregnant Women and Children

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Summary: Researchers have detected biomarkers for the common fungicide azoxystrobin (AZ) in the urine of pregnant women and children between the ages of 40-84 months. In...

This Is What It’s Like to Experience Misogynoir as a Neurosurgery Resident

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Racial and gender disparities are prevalent in various specialties of medicine, including neurology. Although the representation of different ethnic and racial groups in academic neurology has...

Enhancing Pandemic-Sensitive Recruitment Strategies for a Remote, Randomized Placebo-Controlled Trial for Fracture Prevention in...

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Congratulations to Dr Nikolaus Mc Farland for his recent publication, “Enhancing Pandemic-Sensitive Recruitment Strategies for a Remote, Randomized Placebo-Controlled Trial for Fracture Prevention in Patients with...

Increased Mutations in Children Can Be Traced Back to Mistakes in Father’s Sperm

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Summary: Hypermutation in children may be linked to increased mutations in the sperm of the biological father, especially fathers who received certain forms of chemotherapy to...

Air Pollution as a Potential Risk Factor for Epileptic Seizures

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Ambient air pollution breathed daily, specifically related to greater concentrations of carbon monoxide (CO), may be associated with an increased risk for epileptic seizures. It may...

Multiple Sclerosis Patients With Higher B Cell Counts Found to Have a Better Vaccine...

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Summary: Multiple sclerosis patients who take Rituximab have a better response to the COVID-19 vaccine if they have a higher B cell count.Source: Uppsala UniversityMultiple sclerosis...

Impact of Physical Activity on Risk for Disabling Dementia by Gender

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Men who engage in leisure-time moderate to vigorous physical activity (MPVA) may be at lower risk for disabling dementia, according to study findings published in JAMA...

Designer Neurons Offer New Hope for Treatment of Parkinson’s Disease

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Summary: Researchers have designed a new method of converting non-neural cells into functioning neurons that are able to form synapses, dispense dopamine, and restore the function...

Can Childhood Trauma Increase the Risk for Multiple Sclerosis in Women?

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Women who experienced childhood sexual and emotional abuse may have an increased risk of developing multiple sclerosis (MS) later in life, according to study findings published...

The Brain Searches for the Best Way to Move the Body

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Summary: When learning how to coordinate a new movement, the nervous system first explores and evaluates many different coordinated patterns. With experience, the nervous system then...

Prediction Tool Estimates Survival Among Patients With Status Epilepticus

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New neurological deficits increased the risk for long-term mortality among patients with status epilepticus (SE), according to study findings published in JAMA Neurology. Among patients with SE,...

Quantifying Cognitive Decline in Dogs Could Help Humans With Alzheimer’s Disease

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Summary: Researchers have developed a set of tests that can quantify cognitive changes in aging dogs and accurately detect canine cognitive dysfunction syndrome, a disorder with...

SARS-CoV-2 Seroprevalence Up From December 2021 to February 2022

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HealthDay News — From December 2021 to February 2022, the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) increased, reaching about 75% among children and...

Newly Discovered Neural Network Gets Visual and Motor Circuits in Sync

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Summary: Researchers have identified a neural network that connects the legs to the visual system in order to shape walking.Source: Champlimaud Center for the UnknownA fruit...

Patient-Dependent Factors and Decreased PA Pressure Monitoring During the COVID-19 Pandemic

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A loss in treatment effect and reduction in heart failure (HF)–related events were reported during the COVID-19 pandemic, with patient-dependent factors possibly playing a key role...

Promising Alzheimer’s Marker in Blood Prompts Warning About Brain-Boosting Supplements

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Summary: Elevated levels of PHGDH in the blood could signal the earliest stages of Alzheimer’s disease. Researchers caution older adults against using “brain-boosting” supplements that contain...

Age at Menopause Tied to Risk for Aneurysmal Subarachnoid Hemorrhage

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A younger age at menopause and a shorter reproductive life span are associated with a higher risk for aneurysmal subarachnoid hemorrhage (aSAH) in women, according to...

Study Preserves Memory in Mice, Offering Promising New Basis for Active Immunization Against Alzheimer’s...

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Summary: The corn-derived MetO-rich protein, when injected, prompts the immune system to produce antibodies against the MetO component of amyloid beta. Older mice injected with the...

Narcolepsy, Sodium Intake, and Heart Health: This Expert Explains It All

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Neurology practitioners should consider sodium intake and related cardiovascular impacts when making treatment plans for patients with narcolepsy, increasing evidence suggests. Presenting at the 2022 American...

Cutting Calories and Eating at the Right Time of Day Leads to Longer Life...

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Summary: Restricting calories and eating only during the most active part of the day helped extend the lifespan of mice.Source: HHMIOne recipe for longevity is simple,...

Age at Loss of Ambulation Tied to Peak Motor Skills in Patients With DMD

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Among male children with Duchenne muscular dystrophy (DMD), increased motor skills near the age of their expected peak suggest they’ll reach an older age before they...

Multiple Brain Regions Control Speech Found, Challenging Common Assumption

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Summary: Researchers report multiple areas of the frontal lobe control the muscles of vocalizations and could control complex speech. The findings refute the long-standing belief that...

NfL Tied to Effect of Physical Activity on Cognitive Decline Rate

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Medium or high physical activity is associated with decreased rates of cognitive decline among older adults, dependent on their serum neurofilament light (NfL) concentrations, according to...

Advanced diffusion imaging to track progression in Parkinson’s disease, multiple system atrophy, and progressive...

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Congratulations to Drs. McFarland, Okun and Vaillancourt on the publication of “Advanced diffusion imaging to track progression in Parkinson’s disease, multiple system atrophy, and progressive supranuclear...

Why Teens Tune Out to Mom’s Voice

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Summary: At age 13, teenagers no longer find their mother’s voice uniquely rewarding, and tune into unfamiliar voices more. A new study reveals the neurobiology behind...

Sleep Disturbances in Alzheimer Disease Tied to Loss of ‘Wakeful’ Neuron

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The proportion of subcortical wake-promoting neurons was associated with sleep phenotypes among patients with Alzheimer disease (AD) or progressive supranuclear palsy (PSP), according to study findings...

How Neurodiagnostics Is Transforming – Neurology Insights

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Professionals within the neurodiagnostic field are realizing that our brains’ electrical fields can help us understand various diseases in ways we never have — it has...

UF neuroscientists awarded grants to advance Lewy body dementia research » McKnight Brain Institute...

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By Todd Taylor Lewy body dementia is the second-most common form of neurodegenerative dementia in the U.S. behind Alzheimer’s disease. To help combat this growing health issue, which...

Impact of College Personality Course on Personality Understanding

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Summary: Students who participate in psychology classes focused on personality traits show improvements in dispositional intelligence, allowing them to better understand how the behaviors of others...

Temozolomide Bests Nivolumab in Glioblastoma With Unmethylated MGMT Promoter

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Temozolomide plus radiotherapy (RT) should remain the standard first-line treatment for glioblastoma, regardless of MGMT promoter status, according to researchers. Results of a phase 3 trial showed...

A New Treatment Reduces Inflammation in Multiple Sclerosis Mice Models

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Summary: Administering a lipid that mediates inflammation reduced chronic inflammation associated with multiple sclerosis in mouse models. Researchers found these mediator lipids are reduced in humans...

Safety of Prenatal Exposure to Benzodiazepines, Z-Drugs Inconclusive

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Currently, the long-term safety of prenatal exposure to benzodiazepines (BZPs) and z-drugs is inconclusive, according to study findings published in the journal Neuroscience and Biobehavioral Reviews. BZPs...

Clues Into a Sleep Mystery

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Summary: Using gene editing to disrupt a gene in the thalamus that codes for a protein that binds to GABA boosted the activity of delta waves...

MAMS Adaptive Trial Shows Promise for Future Progressive MS Treatments

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Clinical trials have produced remarkable strides in the treatment of multiple sclerosis (MS) in recent decades, especially for patients with the relapsing-remitting form of the disease....

New Brain Learning Mechanism Calls for Revision of Long-Held Neuroscience Hypothesis

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Summary: Experimental observations conclude learning is mainly performed by neural dendrite trees as opposed to modifying solely through the strength of the synapses, as previously believed.Source:...

What Are the Effects of the COVID-19 Pandemic on People With Migraine?

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Among people enduring migraine, the COVID-19 pandemic has led to both positive and negative perceived repercussions, according to study findings published in Headache. People living with migraine...

Development and Validation of Automated Magnetic Resonance Parkinsonism Index 2.0 to Distinguish Progressive Supranuclear...

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Congratulations Drs. David Vaillancourt and Nikolaus McFarland on the publication of “Development and Validation of Automated Magnetic Resonance Parkinsonism Index 2.0 to Distinguish Progressive Supranuclear Palsy-Parkinsonism...

How Effects on the Brain Can Produce Long COVID

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Summary: Immune system mediated injury rather than the virus entering and killing brain cells may explain why people experience long-term consequences associated with COVID-19 infection.Source: YaleCOVID-19...

Patients With Tourette Syndrome Susceptible to Assault, Committing Crimes

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Patients with Tourette syndrome (TS) or chronic tic disorder (CTD) were more likely to be victims of violent crimes or perpetrators of any crimes compared with...

Offspring Weakens When Parents Are Given Antibiotics

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Summary: Zebrafish study finds antibiotics can have detrimental effects on the descendants of those exposed to them, including weaker immune systems.Source: University of Southern DenmarkAntibiotics have...

Efficacy of Different Acupuncture Therapies for Primary Insomnia

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There is a low or very-low certainty of evidence that supports the use of acupuncture for the treatment of insomnia, according to study findings published in...

Some Forms of Alzheimer’s Disease Hit Early in Life, Can We Predict When?

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Summary: Study reveals a direct relationship between changes in amyloid-beta fragments that accumulate in the brains of Alzheimer’s patients and the age at which symptoms of...

Is Breastfeeding Safe for Infants of Women With Epilepsy on Antiseizure Medication?

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Antiseizure medications (ASMs) can be detected in breast milk of women with epilepsy and plasma/serum of infants who have consumed breast milk, according to study findings...

Widespread Brain Receptor Hides Surprising Mechanism of Action

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Summary: Glutamate binds to the subunits of its receptor only in specific patterns. The findings upend previous belief that each subunit binds glutamate independently and points...

Neuro-Visual Deficits Common in Patients With Rehabilitation Needs After COVID-19

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Neuro-visual deficits are common among patients with rehabilitation needs following COVID-19, which highlights the need for multi-professional rehabilitation assessment and intervention, according to a study published...

How Do Our Eyes Stay Focused on What We Reach For?

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Summary: When reaching for a target object, we anchor our gaze to the target of the reach moment, thereby looking at the target for longer periods....

Is Stroke a Common Adverse Event Following COVID-19 Vaccination?

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Among SARS-CoV-2 vaccine recipients in Mexico, less than 1 in a 1,000,000 reported incidence of stroke following immunization, according to study findings published in Neurology. While necessity...

Raise the Minimum Wage to Lower Divorce Rates

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Summary: A UCLA-led study reports states that increased the minimum wage by $1 per hour had a 7-15% reduction in divorce rates among couples earning lower...

The Evolving Role of Neurologists in Autism Diagnosis and Management

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Autism spectrum disorder (ASD) is a set of related and complex neurodevelopmental disorders characterized by persistent deficits in social communication and interaction, and restricted, repetitive patterns...

Study Reveals Set of Brain Regions That Control Complex Sequences of Movement

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Summary: The primary motor and primary somatosensory areas of the brain are involved in controlling immediate motor movements in real-time, while the premotor area appears to...

Outcomes in Patients Receiving Emergency Neurosurgery for Traumatic Brain Injury

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Globally, significant differences have been noted in casemix, management, and mortality of patients who undergo emergency neurosurgery for traumatic brain injury (TBI), according to a prospective,...

Witnessing Parental Domestic Violence in Childhood Linked to Mental Illness in Adulthood

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Summary: Over 22% of adults who were chronically exposed to parental domestic violence as children developed major depressive disorder later in life. 1 in 6 adults...

Recurrent Stroke Rate Among Young Adults With Embolic Stroke of Undetermined Source

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In a large cohort of young adult patients who experience an embolic stroke of undetermined source (ESUS), a relatively low rate of subsequent ischemic stroke has...

Interferon Drives Cognitive Impairment in Alzheimer’s Disease Model

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Summary: Type 1 interferon is a major diver of cognitive impairment and memory loss in mouse models of Alzheimer’s disease. Blocking IFN reversed both cognitive impairments...

Groups Issue Scientific Statement on Acute Stroke Care for Disability or Dementia

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The American Heart Association (AHA) and American Stroke Association (ASA) has issued a joint scientific statement on treatment for acute ischemic stroke (AIS) in the disability...

Drug Reduced Frequency of Breathing Pauses in Sleep Apnea

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Summary: Sulthiame, a CA inhibitor drug, reduced the number of breathing pauses and promoted oxygenation during the night in sufferers of obstructive sleep apnea.Source: University of...

Long-Term Outcomes of Patients With Transient Epileptic Amnesia

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A 10-year follow-up of patients with transient epileptic amnesia (TEA) found that life expectancy is not reduced and that seizures were generally controlled with medication. These...

Machine Learning Predicts Conduct Disorder in Kids

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Summary: A new AI algorithm assesses risk factors across three domains to predict the risk of children developing conduct disorders with a high degree of accuracy.Source:...

FDA Panel Votes on Fixed-Dose Combination Therapy for ALS

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The Food and Drug Administration’s (FDA) Peripheral and Central Nervous System Drugs Advisory Committee voted 4 “yes” and 6 “no” on the question of whether the...

AAN Survey Highlights Gender Disparities in Academic Neurology

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The following article is part of conference coverage from the 2022 American Academy of Neurology (AAN) Annual Meeting. Neurology Advisor’s staff will be reporting breaking news...

Giving Zebrafish Psychotropic Drugs to Train AI Algorithms

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Summary: Researchers trained an AI to determine which psychotropic agent a zebrafish had been exposed to based on the animal’s behaviors and locomotion patterns.Source: St. Petersburg...

Women’s Underrepresentation in Neurology and What to Do About It

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The almost equal entry rate of women into medical schools has been noted as a huge gain. The Association of American Medical Colleges (AAMC) recently shared...

Caffeine Intake and Dementia: Can Lewy Bodies Explain the Link?

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Caffeine intake was inconsistently associated with clinical dementia, according to study findings published in Annals of Neurology. The relationship between habitual caffeine consumption and age-related cognitive impairment...

Cognitive Resilience Proteins May Maintain Brain Health in Older Adults

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The use of interventions that target proteins driving cognitive resilience might have the ability to offset the effects of multiple pathologies. In fact, thousands of proteins...

Human Gene Variant Produces Attention Deficit Disorder-Like Problems in Mice

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Summary: Mice with the Val89 choline transporter variant had reduced rates of choline uptake and a diminished capacity to sustain acetylcholine production during attention-demanding conditions. The...

Does Long COVID After Mild Infection Lead to Small Fiber Neuropathy?

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Patients with long COVID-19 often experience prolonged, disabling, small fiber neuropathy (SFN) within 1 month due to immune dysregulation, according to study findings published in Neuroimmunology...

What Shaking a Container Can Teach Us About Touch

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Summary: Study sheds light on the human ability to understand how an object moves inside a container, revealing how different kinds of information can be conveyed...

Low-Grade Gliomas With Elevated DMD Expression Tied to Shorter Survival

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Alternations in Duchenne muscular dystrophy (DMD) gene expression in low grade glioma (LGG) tumor tissue may be an independent prognostic marker for survival, according to study...

Brainstem Atrophy Is Linked to Extrapyramidal Symptoms in Frontotemporal Dementia

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Summary: Patients who suffer from frontotemporal dementia with extrapyramidal symptoms have brainstem atrophy and reduced metabolic activity in specific brain regions compared to those with FTD...

Abusive Head Trauma May Elevate Intraocular Pressure in Children

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Children with abusive head trauma (AHT) may be at risk for elevated intraocular pressure (IOP), according to a study published in the American Journal of Ophthalmology....

Enhancing Deep Sleep – Neuroscience News

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Summary: SleepLoop, a newly designed mobile system, can help promote deep sleep through auditory brain stimulation. The device tracks when a person enters slow-wave brain activity,...

Specific Muscular Dystrophy Mutational Sites Not Associated With Epilepsy Risk

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No evidence was found to support an association between Dp140 or Dp71 mutational sites with epilepsy risk among patients with muscular dystrophies, according to study findings...

Researchers Have Developed a Russian-Language Method for the Preoperative Mapping of Language Areas

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Summary: Researchers have developed a Russian language protocol for neuroimaging that allows for the mapping of individual language areas of the brain before neurosurgery.Source: HSENeurolinguists from...

Is There a Clinical Role for Sleep Apnea Apps?

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Obstructive sleep apnea (OSA) affects up to 14% of men and 5% of women in the United States, causing significant morbidity and reduced quality of life.1 ...

UF neurologists raise more than $20,000 to help people in Ukraine » McKnight Brain...

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By Michelle Jaffee (From left) Drs. Natalie Buchwald, Meghan Humbert, Anna Khanna and Elsa Rodriguez.Over dinner one evening in early March, University of Florida neurologists Anna Khanna,...

Limited Trunk Movement a Factor in REM Behavior Disorder

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Summary: People who suffer from REM behavioral disorder, a sleep disorder linked to an increased risk of developing Parkinson’s disease, exhibit limited movement of their trunk...

Could Benign Paroxysmal Positional Vertigo Be Related to Migraine?

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The following article is part of conference coverage from the 2022 American Academy of Neurology (AAN) Annual Meeting. Neurology Advisor’s staff will be reporting breaking news...

New Technique Uses the Body’s Naturally Occurring Ions to Help Transmit Data Wirelessly

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Summary: Researchers have created an implantable bioelectronic device with a high-speed, low-power wireless data link that uses ions within the body.Source: Columbia UniversityImplantable bioelectronics are now...

GRN Mutation Carriers Show Metabolic Decline in Predementia Brain

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The following article is part of conference coverage from the 2022 American Academy of Neurology (AAN) Annual Meeting. Neurology Advisor’s staff will be reporting breaking news...

Childhood Emotional Trauma Linked to Heightened Multiple Sclerosis Risk Among Women

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Summary: Women who experienced childhood trauma had an increased risk of developing multiple sclerosis later in life. The evidence suggests childhood abuse and trauma can alter...

Vutrisiran Improves Multiple Symptoms of hATTR Amyloidosis With Polyneuropathy

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The following article is part of conference coverage from the 2022 American Academy of Neurology (AAN) Annual Meeting. Neurology Advisor’s staff will be reporting breaking news...

Examining the Link Between Blood Pressure and Emotions

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Summary: Men with hypertension more often recognized angry expressions when looking at the face of another person. The anger recognition bias contributed to blood pressure increases...

β2-Adrenoreceptor Medications Associated With Lower Risk for Parkinson Disease

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The following article is part of conference coverage from the 2022 American Academy of Neurology (AAN) Annual Meeting. Neurology Advisor’s staff will be reporting breaking news...

Mutations in Noncoding DNA Are Found to Protect the Brain From ALS

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Summary: Mutations in the IL18RAP gene reduce inflammation and appear to protect the brain against ALS.Source: Weizmann Institute of ScienceGenetic mutations linked to a disease often...

Statin Therapy as a Precision Prevention Approach for Neurodegenerative Diseases

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The following article is part of conference coverage from the 2022 American Academy of Neurology (AAN) Annual Meeting. Neurology Advisor’s staff will be reporting breaking news...

Our Brain as a Time Machine and Other Unsolved Questions About the Many-Faceted Mystery...

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Summary: During an upcoming symposium, researchers will discuss the neurobiology of time perception, how emotion shapes our perception of time, and the role of memory in...

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