Motivation Depends on How the Brain Processes Fatigue

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Summary: People show a decrease in motivation to exert effort or work when feeling fatigued. Motivation can be restored if people are allowed a short rest,...

Patients with MS and Depression During Pregnancy Have Prolonged Depressive Symptoms

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Women with multiple sclerosis (MS) who experience depression onset during pregnancy had more prolonged depressive symptoms, often lasting into the postpartum period, according to an editorial...

Many Parents Still Believe Boys Are Better, More Competitive at Sports Than Girls

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Summary: Gender stereotypes and double standards, where young female athletes are not taken as seriously as or treated differently than their male counterparts, persist, even amongst...

Multispecialty Perspectives on Long COVID-19

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In the year since the global COVID-19 pandemic was declared in March 2020 by the World Health Organization,1 short-term treatments such as prone positioning of patients2...

65+ and Lonely? Don’t Talk to Your Doctor About Another Prescription

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Summary: Researchers say older adults who feel lonely are twice as likely to use opioids to control pain, and 2.5 times more likely to be prescribed...

Tissue Biopsy for Progressive Bilateral Optic Neuropathy Diagnosis: A Case Report

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A case report of a patient presenting with bilateral vision loss led to the diagnosis, on the basis of tissue biopsy, of progressive bilateral optic neuropathy....

The Future of Psychedelic Science

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Summary: From treating depression and other mental health disorders, to helping relieve chronic pain, researchers discuss the advantages and implications of psychedelic treatments.Source: Imperial College LondonFrom...

Procedural Sequence Learning, Event File Binding Mechanisms in Tourette Syndrome

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In patients with Gilles de la Tourette syndrome (GTS), both procedural sequence learning and event file binding are enhanced and are potential cognitive mechanisms behind habitual...

What Types of Memories Are Forgotten in Alzheimer’s Disease?

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Summary: Reduction of semantic memory could be an indicator of Alzheimer’s disease 12 years before onset. Researchers examine different types of memory loss associated with dementia.Source:...

The perilous neurological conundrums of pregnancy and their checklists – The Neurology Lounge

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Neurologists are often slightly nervous when their patients start planning a family. It’s even worse when the patients fall pregnant–unexpectedly. This is because neurologists need super...

Broad Range of Drug-Drug Interactions in Migraine Prevention and Treatment

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A narrative review emphasized that drug-drug interactions (DDIs) should be taken into consideration when formulating a treatment plan for patients with migraine, according to findings published...

Status Epilepticus: Hiding in Plain Sight

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It was meant to be a fun take-your-daughter-to-work day: Dr. Anna-Marie Beck brought her five-year-old daughter, Addison, into the lab to demonstrate to her students how...

Brain-Repair Discovery Could Lead to New Epilepsy Treatments

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Summary: Microglia do not only remove damaged materials following a seizure, they also appear to heal damaged neurons.Source: University of VirginiaUniversity of Virginia School of Medicine...

Cost Savings Linked to First-Pass Effect in Acute Ischemic Stroke Treatment

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In the US, a person suffers from stroke every 40 seconds, while someone dies from stroke every 4 minutes.1 As one of the leading causes of...

Pandemic Changed Perceptions of Masked Faces

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Summary: The COVID-19 pandemic has had a significant effect on our perceptions of facemask wearers. Those who wore facemasks were considered healthier and more attractive than...

Evaluating Transcranial Magnetic Stimulation Technologies: Deep vs Traditional

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People with depression can live with symptoms for long periods of time before finding a treatment that works. Failure around depression treatments can be a result...

UF neuroscientists discover biomarker with potential to aid Parkinson’s diagnosis » McKnight Brain Institute...

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By Michelle Jaffee (From left) Drs. Habibeh Khoshbouei, Adithya Gopinath and Wolfgang StreitUniversity of Florida neuroscientists have developed a new assay, or test, to detect minute amounts...

Unleashing Treg Cells May Lead to Treatments for Multiple Sclerosis

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Summary: Piezo1 limits the potential of regulatory T cells (Treg) to mitigate autoimmune neuroinflammation. Inhibiting Piezo1 could lead to new treatments for autoimmune disorders like multiple...

Impact of Alemtuzumab on the Visual System in Patients with Multiple Sclerosis

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Among patients with multiple sclerosis (MS), treatment with alemtuzumab may result in partial lesion remyelination and may have neuroprotective and promyelinating effects, according to study results...

Non-Neuronal Cells Drive Sex Differences in Early Brain Development

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Summary: Thrombospondin-2, a protein with cell adhesion properties usually secreted by astrocytes, prompted a strong increase in synapses in male-derived neurons but showed no effect in...

Chronic Insufficient Sleep Widespread Among Active-Duty Sailors in the US Navy

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A cross-sectional study of sailors assigned to naval warships in the United States found that workload and uncomfortable mattresses could be targeted to address chronic insufficient...

Researcher earns diversity supplement for dementia with Lewy bodies grant » McKnight Brain Institute...

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(From left) Melissa Armstrong, M.D., M.Sc and Joshua Brown, Pharm.D., Ph.D.By Eli Golde Joshua Brown, Pharm.D., Ph.D., recently received an NIH National Institute on Aging diversity grant...

Autism Can Be Detected During Toddlerhood Using a Brief Questionnaire

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Summary: A newly developed questionnaire can detect autism in children between the ages of 18 to 30 months.Source: University of CambridgeNew research led by the University...

Pachymeningitis Diagnosis in Patient With Crohn Disease and Relapsing Polychondritis

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A case report described the first instance of a patient with Crohn disease (CD) and relapsing polychondritis (RP) presenting with pachymeningitis, according to study  findings published...

Hope For Psychosis Sufferers – Neuroscience News

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Summary: A new model of schizophrenia opens the door to a better understanding of, and therapeutic options for brain dysfunction that is at the root of...

45 eponymous neurological disorders and their practical checklists – The Neurology Lounge

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Neurology is full of syndromes named after their discoverers. These diseases are defined by their eponyms. Many of these eponymous disorders are very common and...

Trigeminal Neuralgia: A Rare Facial Pain Condition Comprising 3 Distinct Subtypes

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A narrative review published in Headache found that research into all aspects of trigeminal neuralgia (TN) is needed to streamline accurate diagnosis and treatment success. TN is...

How Social Discrimination Affects the Brain

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It has become clear that racism and other forms of social discrimination have a negative impact on health outcomes. Only recently, though, have scientists begun to...

Fixel Institute launches neurotech lab » McKnight Brain Institute » University of Florida

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By Michelle Jaffee The neurotechnology lab of Christopher Butson, Ph.D., is the newest research space to launch within the Norman Fixel Institute for Neurological Diseases at UF...

Climate Changed the Size of Our Bodies and, To Some Extent, Our Brains

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Summary: A new study reveals the impact climate played in the evolution of the human brain and body. Studying 300 fossils from the genus Homo found...

Racial Disparities in the Diagnosis of Autism Spectrum Disorder

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There are significant racial inequities existing in access to services for youth with autism spectrum disorder (ASD). Multiracial children are diagnosed with ASD later than their...

Resilience Is Dynamic, Not a Static Character Trait

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Summary: Resilience fluctuates because it encompasses the way individuals respond to a variety of circumstances over time.Source: North Carolina State UniversityA new study finds that resilience...

Osmophobia May Be a Clinical Diagnostic Marker of Pediatric Migraine

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Osmophobia, defined as aversion to or dislike of odors, could be a clinical diagnostic marker for migraine among children and adolescents, according to a letter to...

How Do We Know Where Things Are?

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Summary: A new study reveals how the visual system stabilizes and what happens when we shift our vision by moving our eyes.Source: Dartmouth CollegeOur eyes move...

Consensus-Based Management of Opioid Misuse, Opioid Use Disorder in Cancer

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A study on the proper management of patients with serious illnesses who misuse opioids or have opioid use disorder is currently underway, the results of which...

Air Pollution Exposure Linked to Poor Academics in Childhood

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Summary: Early-life exposure to high levels of air pollution was associated with poor inhibitory control during later childhood and poorer academic performance during adolescence.Source: Columbia UniversityChildren...

Variation in Neurologic Criteria Protocols for Pediatric Brain Death in the United States

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Protocols for death by neurologic criteria (DNC) differ among pediatric institutions in the United States. A cross-sectional study of these protocols found that aligning institutional practices...

Preferred Life Expectancy and Its Association With Hypothetical Adverse Life Scenarios

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Summary: The desire of older adults to live to an advanced aged was significantly reduced by hypothetical adverse life events, such as the prospects of developing...

Pediatric Communicating Hydrocephalus With Intraventricular CSF Turbulence: Case Report

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This was a case report of a pediatric patient presenting with progressive macrocephaly that was published in Neurology. The patient was given a ventriculoperitoneal shunt which...

Why Some People Overestimate Their Abilities While Others Underestimate

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Summary: Lacking confidence in our own ability may stem from overestimating the abilities and performance of others, researchers say.Source: University of AlbertaA lack of confidence in...

the complete checklists – The Neurology Lounge

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Of all the disorders neurologists have to deal with, few have as many subtypes as spinocerebellar ataxia (SCA). Most neurologist are familiar with the...

SARS-CoV-2 May Be Linked to Immune-Mediated Myopathy

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Compared with patients who die without COVID-19 infection, patients who die with severe COVID-19 may present with signs of mild to severe myositis, suggesting that SARS-CoV-2...

Is Burnout Worse Post-COVID? – Neurology Insights

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As the country opens back up, pre-pandemic stressors will make their way back into neurology practice.Only now, there are additional challenges in running a practice brought...

Deep brain stimulation settings may be successfully managed at home after surgery, study shows

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New research published today shows that people receiving deep brain stimulation, or DBS, for the treatment of Parkinson’s disease may be managed successfully at home by...

Vocal Music Boosts the Recovery of Language Functions After Stroke

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Summary: Stroke survivors who listened to vocal music had improved recovery of structural connectivity of language networks in the left frontal lobe compared to those who...

Exploring Aspirin for the Treatment and Prevention of Migraines

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Migraine is a common neurological condition and one of the largest causes of disabilities worldwide. Despite this, the condition is both underdiagnosed and undertreated. Over 90%...

Does Physician Burnout Impact Patient Experience?

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Burnout is becoming an increasingly hot topic in the physician community.But, in addition to the concerns about mental well-being, physicians should also be wary of the...

What Is Daydreaming? Parts of the Brain Show Sleep-Like Activity When Your Mind Wanders

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Summary: Daydreaming and mind-wandering appear to occur when parts of the brain fall asleep while other areas remain awake.Source: The ConversationOur attention is a powerful lens,...

Kappa-Free Light Chain Index Predicts Early Multiple Sclerosis Disease Activity

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A high κ-free light chain (κ-FLC) index may predict early disease activity in multiple sclerosis (MS) and, compared to determination of cerebrospinal fluid (CSF)-restricted oligoclonal band...

Work Like a Dream: New Anticholinergic Drug Keeps PTSD Flashbacks and Nightmares Away

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Summary: Trihexyphenidyl, an anticholinergic medication commonly prescribed for Parkinson’s symptoms, appears to alleviate negative memory flashbacks and nightmares experienced by those with PTSD.Source: Cactus CommunicationsPost-traumatic stress...

Understanding the Relationship Between Alzheimer Disease and HIV

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Cognitive decline associated with human immunodeficiency virus (HIV) may be secondary to HIV-associated neurocognitive disorder (HAND) or due to true Alzheimer disease (AD); new tools may...

Parellel Distributed Processing, the Basal Ganglia, and Evolution » Department of Neurology » College...

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Congratulations Dr. Stephen Nadeau, on the publication of “Neural Population Computing: Parellel Distributed Processing, the Basal Ganglia, and Evolution,” in the Journal of Experimental Neurology.   Abstract Representations in...

Digital Pens Provide New Insight Into Cognitive Testing Results

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Summary: Performing written cognitive tests with a digital pen allowed researchers to identify differences between “thinking” and “writing” times that may be early biomarkers for cognitive...

Case Study: Herpes Zoster in Patients With MS Treated With Dimethyl Fumarate

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A reduction of CD8+ T-cells coupled with increased natural killer (NK) cells associated with dimethyl fumarate (DMF) therapy for multiple sclerosis (MS) may have important implications...

Structures Discovered in Brain Cancer Patients Can Help Fight Tumors

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Summary: Researchers found lymph-node-like structures close to glioma brain tumors in cancer patients. The study reveals immune cells within these structures can be activated to attack...

Steroids Not Indicated for Every Patient with MS-Related Optic Neuritis

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Despite its side effects, intravenous methylprednisolone is still used by many ophthalmologists and neurologists to treat multiple sclerosis (MS)-related demyelinating optic neuritis, according to researchers. However,...

Researchers Reduce Severity of Sleep Apnea by at Least 30%

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Summary: Two existing medications have been repurposed to treat sleep apnea. Researchers report the medications reduce symptoms of sleep apnea by 30%.Source: The Physiological SocietyNew research...

Language Development of Children of Women With Epilepsy Similar to Those of Healthy Women

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Language development of children of women with epilepsy (WWE) taking antiseizure medications do not tend to differ from children of healthy women when assessed at 2...

Study Pinpoints Role of Dopamine in Songbird’s Brain Plasticity

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Summary: Dopamine drives neuroplasticity in the auditory pallium region of the zebra finch brain, researchers report.Source: UMassNeuroscientists at the University of Massachusetts Amherst have demonstrated in...

21 unusual headache syndromes and their demystifying checklists – The Neurology Lounge

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Headaches constitute the bulk of what neurologists see in their general clinics. Most people with headaches fall neatly into one of two categories, migraine or tension...

Biological Purpose of Near Death Experiences Uncovered

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Summary: Human near-death experiences may have arisen from an evolutionary mechanism, researchers report.Source: University of LiegeNear-death experiences are known from all parts of the world, various...

Lecanemab Gets Breakthrough Tx Status for Alzheimer Disease

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Topics » Alzheimer's Disease and Dementia

Understanding Pathogenesis of Neurologic Impairments in Patients With COVID-19

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Although encephalopathies in patients with severe SARS-CoV-2 infection are not due to major viral infections in the brain or cytokine storm leakage from the periphery into...

How Pursuing Higher Education and Can Move Your Career Forward

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Too often neurodiagnostic technologists are under-recognized in their institutions and miss out on policy discussions and salary bumps. The shift to online education we’ve seen in...

How Environmental Factors Could Provide for a Young Brain

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Summary: Growing up and experiencing stimulating environments throughout life help to keep the hippocampus “young”, and can help to preserve mental fitness in old age.Source: DZNEA...

New Position Statement on the Importance of Sleep to Health and Well-Being

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An American Academy of Sleep Medicine position statement published in the Journal of Clinical Sleep Medicine focused on the importance of sleep to health and provided...

Gut Microbe Secreted Molecule Linked to Formation of New Nerve Cells in Adult Brain

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Summary: Gut microbes that metabolize tryptophan secrete indoles that stimulate the development of new neurons in the adult brain.Source: SinghealthThe billions of microbes living in your...

Importance of Antibody Binding Patterns in Inflammatory Demyelinating Diseases

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Differential binding of serum immunoglobulin G (IgG) antibodies to major isoforms of myelin oligodendrocyte glycoprotein (MOG) in inflammatory demyelinating diseases is associated with clear structural differences...

Toxicity of Protein Involved in Alzheimer’s Triggered by a Chemical ‘Switch’

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Summary: Study identifies specific chemical features of tau that may cause it to accumulate in the brain and trigger Alzheimer’s disease.Source: Tokyo Metropolitan UniversityResearchers from Tokyo...

Gender-Specific Risk Profiles for Acute Ischemic Stroke

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The risk factor profile for acute ischemic stroke (AIS) differed on the basis of gender, according to results of a population-based cross-sectional study, published in BMC...

Researchers Find the Adhesions That Build the Brain’s Networks

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Summary: The hepaCAM protein plays a critical role in the communication and coordination of astrocytes as they build synapses. The findings shed new light on potential...

10 perceptively catchy neuroscience titles – The Neurology Lounge

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The brain is arguably the most mysterious entity in the universe. It surprises us every time we believe we have got a handle on...

Patient-Identified Most Bothersome Chronic Migraine Symptom: Promising Clinical Research Endpoint

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Eptinezumab therapy for chronic migraine is associated with more improvement in patient-identified most bothersome symptoms compared with placebo, demonstrating that patient-identified most bothersome symptom is a...

Taking EEG Knowledge Abroad – Neurology Insights

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The COVID-19 shutdowns last year were not enough to deter Lauren Feltz from doing the international mission work she loves.For the intraoperative neuromonitoring (IONM) technologist, pursuing...

Florida’s Alzheimer’s research consortium awarded $15 million grant to focus on diverse populations

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The 1Florida Alzheimer’s Disease Research Center, or 1Florida ADRC, a University of Florida-organized consortium of leading research institutions aimed at making Alzheimer’s and related dementias treatable,...

Cancer Survivors’ Tongues Less Sensitive to Tastes Than Those of Healthy Peers

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Summary: Changes in taste perception can for years following chemotherapy and radiotherapy treatments for cancer, a new study reports. Cancer survivors reported less sensitivity to bitter,...

Comprehensive Multidisciplinary Care is Essential for Autoimmune Neurologic Disorders

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A comprehensive approach to care is important for patients with autoimmune neurologic disorders.  In a review article published in Neurology, study authors discussed the importance of...

A Low Omega-3 Index Is Just as Strong a Predictor of Early Death as...

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Summary: People with lower EPA and DHA in red blood cell membranes, which correlates to lower scores on the Omega-3 index, were found to have an...

Systematic Pain Review Sets the Stage for a Gold Standard of Patient Care

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The lack of a gold standard to compare pain mechanism categories (PMCs) in the pain management field represents an urgent research need, and expert consensus according...

Melatonin in Mice: There’s More to This Hormone Than Sleep

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Summary: In mice, natural melatonin is linked to a pre-hibernation state, allowing for a slower metabolism and survival when food is scarce or the temperature is...

Parkinson Disease-Related Brain Metabolic Patterns as Phenoconversion Biomarker

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De novo Parkinson disease (PD)-related brain metabolic patterns may be an effective neuroimaging biomarker that highlights metabolic alterations in the prodromal stage of PD, prodromal Lewy...

Self-Reported Declines in Cognition May Be Linked to Changes in Brain Connectivity

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Summary: Self-reported cognitive decline was associated with altered functional connectivity in the hippocampus and dorsal anterior insular, a new study reports.Source: Wayne State University Jessica Damoiseaux, Ph.D.,...

Long-term Safety of Onasemnogene Abeparvovec in Spinal Muscular Atrophy

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In infants with spinal muscular atrophy type 1, treatment with a single dose of onasemnogene abeparvovec provides a continued monitorable and manageable safety profiles up to...

Did Neurotoxins Cause the Salem Witch Trials?

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In the fall of 1691, crop failures in Salem Village, Massachusetts, forced residents to switch from making wheat bread to rye bread.By 1693, 175 people had...

Investigational Alzheimer’s Drug Improves Biomarkers of the Disease

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Summary: Gantenerumab, an investigational drug for Alzheimer’s disease, reduced amyloid plaques and lowered tau levels in the brains of people with genetic risk factors for the...

Timely Endovascular Thrombectomy Imperative for Favorable Post-Stroke Outcomes

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Among patients with acute ischemic stroke, every 1 second delay in endovascular thrombectomy (EVT) treatment success is associated with a 2.4-hour loss of healthy life, according...

Pregnant Women With Migraine at Higher Risk of Complications

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Summary: Pregnant women with a history of migraines are at greater risk of both prenatal and postnatal complications. A new study found migraine sufferers are at...

Predicting Recovery of Patients With Post-Traumatic Trigeminal Neuropathy

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Subjective well-being may be a contributing factor for neurosensory recovery following post-traumatic trigeminal neuropathy (PTN). These findings from a prospective observational study were published in The...

Details Behind the Body’s Response to Stress Revealed

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Summary: Study reveals how key proteins regulate the brain’s response to stress in the hippocampus.Source: McLean HospitalThe biological mechanisms behind stress-related psychiatric conditions, including major depressive...

The 130 manifestations of hereditary spastic paraparesis – The Neurology Lounge

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The hereditary spastic paraplegias (HSP) are a diverse group of inherited disorders of the spinal cord. They may be transmitted dominantly or recessively, and through...

Commentary: Neurologists on Palliative Care Communication

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Among the most powerful instruments of healing are patients’ relationships with their doctors or clinicians. Feeling seen and valued by the clinicians they trust helps patients...

Pediatric ADHD Treatment & Medication

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By: Dr. Ellen Edgar  -  no responses  -  Neurological BlogAttention Deficit Hyperactivity Disorder, also known as ADHD, is a neurodevelopmental disorder found in children who have difficulty paying attention or...

Stress During Pandemic Linked to Poor Sleep

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Summary: A new study sheds light on how COVID-19 has impacted sleep and mental health. Researchers found 32.9% of people reported a decrease in sleep and...

Childhood TBI Causes Widespread and Persistent White Matter Disruption

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Following moderate to severe traumatic brain injury (msTBI) in children, white matter disruption was widespread, persistent, and impacted by demographic and clinical factors, according to study...

Congratulations to the Neurology Diversity and Inclusion Council! » Department of Neurology » College...

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Our Neurology Diversity and Inclusion Council’s accomplishments and initiatives were selected as a finalist for the GME IDEA (Inclusion, Diversity, Equity and Access) Champion Award. The award...

P-Glycoprotein Removes Alzheimer’s-Associated Toxin From the Brain

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Summary: P-glycoprotein, a critical toxin pump in the body, has the ability to remove amyloid plaques from the brain. Researchers say increasing P-gp in the blood-brain...

Post-Traumatic Coma Prognosis is Difficult to Predict

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Although favorable outcomes are possible among young patients with post-traumatic coma, even following prolonged coma and in the presence of radiographic evidence of brainstem injury, it...

New Treatment Stops Progression of Alzheimer’s Disease in Monkey Brains

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Summary: Elderly monkeys treated with CpG ODN had 59% fewer deposits of Alzheimer’s related plaques in their brains compared to those who did not receive the...

Essential Tremor: Implications in Heterogeneous Motor Phenomenology

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Essential tremor may present with co-occurrence of other neurological disorders in the same individual or in multiple individuals in the same family; this may result in...

Speech Droplets Drive Transmission of COVID-19

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Summary: Speaking without a facemask in confined spaces poses the biggest risk for spreading SARS_CoV_2, the virus responsible for COVID-19.Source: WileyA new review published in the Journal...

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