Summary: Genetic factors are responsible for childhood anxiety and depression that persists during adulthood.

Source: University of Queensland

Hereditary factors are partly responsible for childhood anxiety and depression that persists into adulthood, according to University of Queensland researchers.

In the largest study of its kind in the world, the genetics of 64,641 children, aged between 3 and 18 years, were analyzed using longitudinal data from the Early Genetics and Lifeforce Epidemiology consortium.

Professor Christel Middeldorp, who holds a co-joint appointment with the UQ Child Health Research Centre and Children’s Health Queensland, said the study showed children who had similar levels of anxiety and depression were also alike genetically.

“It also revealed a genetic overlap between childhood and adult mental health disorders when comparing the results in this childhood study with results of previous studies in adults.

“These findings are important because they help identify people most at risk of symptoms continuing across the lifespan, so intense treatment can be provided where needed,” Professor Middeldorp said.

It’s the first time researchers have conducted such a large scale study examining the role of genetics in repeated measures of anxiety and depression in children.

Professor Middeldorp said genetic variants needed to be investigated because they increased the risk of recurrence and co-occurrence with other disorders.

“Mental health symptoms often come together, so those who experience anxiety or depression have a greater risk of disorders such as ADHD, aggressive behavior,” she said.

Professor Middeldorp said genetic variants needed to be investigated because they increased the risk of recurrence and co-occurrence with other disorders. Image is in the public domain

“We found that this co-occurrence is also due to genetic variants” Professor Middeldorp said.

Genetics account for around 40% of a person’s risk of suffering anxiety and depression, with environmental factors accounting for the rest.

Professor Middeldorp said while everyone could feel anxious or depressed from time to time, some people were better able to adjust to life’s circumstances.

“People with an anxiety disorder ruminate about their situation, preventing them from moving on,” she said. “There is a difference in how people respond to stressors, and part of that difference is genetic.”

Researchers will now analyze the interplay of genetics and environmental variables, such as school and family life, to see how together they influence childhood anxiety and depression.

About this genetics and mental health research news

Author: Press Office
Source: University of Queensland
Contact: Press Office – University of Queensland
Image: The image is in the public domain

Original Research: Open access.
“Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms” by Eshim S. Jami et al. Journal of the American Academy of Child and Adolescent Psychiatry


Abstract

See also

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Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

Objective

To investigate the genetic architecture of internalizing symptoms in childhood and adolescence.

Method

In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument.

Results

The meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, neffective = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%-8.18%).

Additive genetic effects on internalizing symptoms appeared to be stable over age, with overlapping estimates of SNP heritability from early childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the well-being spectrum (|rg| > 0.70), as well as with insomnia, loneliness, attention-deficit/hyperactivity disorder, autism, and childhood aggression (range |rg| = 0.42-0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa.

Conclusion

Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way to future GWAS success.



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