Summary: Stem cells collected from the placentas of women who gave birth to healthy babies could reduce neuroinflammation and reduce brain injury in growth-restricted babies.

Source: University of Queensland

The placenta from mothers of healthy newborns could one day be used to reduce brain injury in growth-restricted babies, according to University of Queensland research.

Dr. Julie Wixey from UQ’s Centre for Clinical Research said the study found stem cells sourced from a healthy placenta may reduce damaging inflammation in these babies after only three days.

“There is currently no treatment to protect the brains of a growth-restricted baby,” Dr. Wixey said.

“Up to 50 percent of them have long-term issues ranging from mild learning and behavioral disorders all the way through to cerebral palsy.

“We know there’s inflammation in the brain and it doesn’t cease once these babies are born.

“Our study has shown we could reduce inflammation and ongoing brain injury by treating these newborns on the day they’re born using a combination of two types of stem cells—endothelial colony forming cells and mesenchymal stromal cells—isolated from a healthy human placenta.”

About 32 million growth-restricted babies are born around the world each year, with around 10 percent of newborns in Australia affected.

These babies fail to grow normally in the womb, often because they haven’t received enough nutrients and oxygen from the placenta.

These babies fail to grow normally in the womb, often because they haven’t received enough nutrients and oxygen from the placenta. Image is in the public domain

“Our research has found after just three days, the combination stem cell therapy not only reduced inflammation but also, importantly, appeared to repair damaged blood vessels in the brain in animal models,” Dr. Wixey said.

“We’re really excited by the outcomes of this study and we hope it’ll improve these babies’ lives long term.”

The patent technique for harvesting stem cells from the placenta was co-invented by UQ’s Professor Kiarash Khosrotehrani and Dr. Jatin Patel—now at the Queensland University of Technology (QUT).

“This has been a fantastic collaborative study and demonstrates the exciting potential of stem cell therapy in the near future in treating unwell babies,” Dr. Patel said.

“We are now working towards scaling up our patented stem cell technology, that will result in greater quantities of cells to drive and expand the preclinical animal studies with the aim of progressing towards a human trial.”

The researchers will now investigate the longer-term outcomes of the combination stem cell treatment.

About this neurodevelopment research news

Author: Press Office
Source: University of Queensland
Contact: Press Office – University of Queensland
Image: The image is in the public domain

Original Research: Open access.
“Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn” by Kirat K. Chand et al. npj Regenerative Medicine


Abstract

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Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being common. There are no current treatments to protect the FGR newborn from lifelong neurological disorders.

This study examines whether pure foetal mesenchymal stromal cells (MSC) and endothelial colony-forming cells (ECFC) from the human term placenta are neuroprotective through modulating neuroinflammation and supporting the brain vasculature.

We determined that one dose of combined MSC-ECFCs (cECFC; 106 ECFC 106 MSC) on the first day of life to the newborn FGR piglet improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation and improved adverse neuronal and white matter changes present in the FGR newborn piglet brain. These findings could not be reproduced using MSCs alone.

These results demonstrate cECFC treatment exerts beneficial effects on multiple cellular components in the FGR brain and may act as a neuroprotectant.



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