Bittersweet Effects of Stevia Uncovered

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Summary: The natural sweetener Stevia disrupts communication between different bacteria in the gut.Source: Ben-Gurion University of the NegevAccording to a new study by Ben-Gurion University of...

Brain structures and networks responsible for stimulation‐induced memory flashbacks during forniceal deep brain stimulation...

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Congratulations to Drs. Wissam Deeb, Leonardo Almeida, Kelly D. Foote  and Michael S. Okun on the publication of “Brain structures and networks responsible for stimulation‐induced memory...

Special programs this holiday season! » Department of Neurology » College of Medicine »...

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Upcoming programs and events Support GroupsAlzheimer’s Association support groups, conducted by trained facilitators, are a safe place for you to share stories and discuss challenges and possible...

Do you have Brain Inflammation? How to know and what to do

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Do you have any of the symptoms of brain inflammation, also called neuroinflammation, listed below? Brain inflammation doesn’t hurt like an inflamed ankle would. Instead it...

The 52 variants of CMT… and their practical checklists – The Neurology Lounge

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Jean-Marie Charcot, Pierre Marie, and Howard Henry Tooth will be confounded to see what has become of the disease they described hundreds of years ago. Charcot-Marie...

Case Study: Teenage Patient With COVID-19 Experiences Severe Encephalopathy

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A recently published case study described a case of severe encephalopathy associated with coronavirus disease 2019 (COVID-19) in a pediatric patient who developed clinical features characteristic...

The Power of Touch: How Physical Contact Can Reshape the Clinical Exam ─ Part...

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This is Part 2 of a 2-part series related to the power of touch in the clinical medical environment. In Part 1, we review the history and...

Long-Term Outcomes of New Onset Super Refractory Status Epilepticus

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Findings from a case series suggest that the majority of patients with new-onset refractory status epilepticus (NORSE) had the more severe new-onset super refractory status epilepticus...

FDA Committees Vote on Novel Therapy for Schizophrenia, Bipolar I Disorder

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The Food and Drug Administration (FDA)’s Psychopharmacologic Drug Advisory Committee and the Drug Safety and Risk Management Advisory Committee jointly voted on ALKS 3831 (olanzapine/samidorphan; Alkermes),...

Cognitive Fatigue and Circadian Cortisol Regulation in Multiple Sclerosis

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Cortisol levels are increased in patients with multiple sclerosis (MS) compared with healthy controls, with slightly higher levels among those with MS without than those with...

Expert Consensus Statement: Determining Brain Death/Death by Neurologic Criteria

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Experts in brain death/death by neurologic criteria (BD/DNC) have convened to publish a consensus statement on global recommendations for determining brain death/death (BD/DNC) by neurologic criteria,...

Shared Underlying Pathways Found for Fatigue and Depression in MS

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Proinflammatory cytokines, tryptophan catabolites, and the gut-brain axis may have key roles in the mechanisms underlying chronic fatigue and symptoms associated with major depressive disorder (MDD)...

Stem Cell-Derived Neurons Provide Clues Into Parkinson Disease

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Human midbrain dopamine neurons transplanted into the nigra were able to be specifically projected to the dorsal striatum. These and other findings in a recent study...

Multi-Strain Probiotic Reduces Constipation in Parkinson Disease

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A multi-strain probiotic consisting of 8 different commercially available bacterial strains reduced constipation in patients with Parkinson Disease (PD), according to study results published in Neurology. Constipation...

How a Difficult Childhood Makes It More Likely You’ll Have Mental and Physical Health...

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Summary: Researchers explore the link between childhood trauma and the increased risk of developing mental and physical health problems as adults.Source: The ConversationDecades of research shows how negative...

New Case Definition Proposed for Acute Fulminant Cerebral Edema in Children

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Study researchers proposed a case definition for acute fulminant cerebral edema (AFCE) based on a clinical profile of patients from the California Encephalitis Project (CEP), according...

Safety and Efficacy of Eculizumab in Patients with Refractory Myasthenia Gravis

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In patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (MG), treatment with eculizumab, a humanized monoclonal antibody that binds to the human C5 complement protein,...

The 7 most hazardous occupations to the nervous system – The Neurology Lounge

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A critical part of history taking in medicine is establishing the occupation of the patient. This is because occupational activities and work place exposures are often...

The Glymphatic System: Importance of Sleep for Clearance of Brain Protein Waste

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The glymphatic system, which is most active during sleep, clears the brain of protein waste products, and degradation of this system over time may be linked...

Remote Ischemic Post-Conditioning With IVT May Improve Acute Ischemic Stroke Recovery

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Repeated remote ischemic post-conditioning (RIPC) combined with intravenous thrombolysis (IVT) can promote nerve function recovery and improve prognosis in patients with acute ischemic stroke, according to...

Inertial Sensor-Based Gait Measures for Fatigue in Multiple Sclerosis

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The level of fatigue in patients with multiple sclerosis (MS) can be predicted based on spatio-temporal gait measures from an Inertial Measurement Unit (IMU) based system,...

New Guidelines for the Management of Lyme Disease

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The Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology collaborated to provide new clinical practice guidelines for the prevention, diagnosis,...

5 years and beyond » Department of Neurology » College of Medicine » University...

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Congratulations to Drs. Takashi Tsuboi Janine Lemos Melo Lobo Jofili Lopes, Kathryn Moore, Bhavana Patel, Joseph Legacy, Adrianna M. Ratajska, Dawn Bowers, Robert S. Eisinger, Leonardo Almeida , Kelly...

How Herpes Infection May Impair Human Fetal Brain Development

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Summary: Herpes virus simplex type 1 infection can spread to the fetal brain during pregnancy, resulting in an increased risk of neurodevelopmental disabilities and neurological deficits.Source:...

5 Dietary Factors Affecting Glaucoma Risk

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January is National Glaucoma Awareness Month. As glaucoma is insidious, and it cannot be cured and its effects cannot be reversed, ophthalmologists are well positioned to...

Nociceptive Pain, Mixed Pain State Often in People With Chronic Pain and MS

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Many people living with chronic pain and multiple sclerosis (MS) often experience pain featuring a combination of nociceptive, nociplastic, and/or neuropathic pain characteristics, according to study...

Basal Ganglia Pathways Associated with Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome »...

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Congratulations Drs. Aysegul Gunduz, Wei Hu, Kelly Foote, and Michael Okun, on the publication of “Basal Ganglia Pathways Associated with Therapeutic Deep Brain Stimulation for Tourette...

FDA Authorizes COVID-19 Test That Provides Rapid Results at Home

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The Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to Lucira Health for its at-home molecular test intended to detect severe acute...

Is Your Headache a Pain in the Neck?

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By: Dr. Ellen Edgar  -  no responses  -  Back & Neck Pain TreatmentThere are so many different types of headaches and headache causes that sometimes, people just learn to live...

Next-Generation Sequencing Helps Identify Neurodevelopmental Disorders

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Next-Generation Sequencing (NGS) is being used with increasing frequency to diagnose neurodevelopmental disorders including epilepsy, autism spectrum disorder (ASD), and intellectual disability. With more studies available...

Maternal Use of Anti-Seizure Drugs, Risk of Autism and ADHD in Offspring

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Maternal use of valproic acid during pregnancy may increase the risk for autism spectrum disorders (ASD) and attention-deficit and hyperactivity disorder (ADHD) in children, while lamotrigine...

The Role of Renin-Angiotensin System in the Pathophysiology of Migraine

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While it does not influence migraine severity, the renin-angiotensin system (RAS) has an important role in the pathophysiology of migraine. Serum levels of angiotensin converting enzyme...

Exposure to Metals Can Impact Pregnancy

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Summary: Prenatal exposure to metals including lead, nickel, and cobalt, may disrupt the endocrine system. The disruptions may contribute to health and disease risks for the...

Vimpat Approved for Primary Generalized Tonic-Clonic Seizures

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The Food and Drug Administration (FDA) has approved Vimpat® (lacosamide; UCB) as adjunctive therapy in the treatment of primary generalized tonic-clonic seizures in patients 4 years of...

How to Treat Migraines when You Can’t Take OTC Treatments

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By: Dr. Ellen Edgar  -  no responses  -  Migraine & HeadacheMigraines are extremely painful and debilitating headaches that can interfere with your daily life and activities to a great degree....

Longitudinal Changes in Dopamine Transporter Predict Neurodegenerative Risk in iRBD

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Baseline and long-term monitoring of changes in the dopamine transporter (DAT) availability may help identify patients with idiopathic rapid-eye-movement sleep behavior disorder (iRBD) who are at...

Do Neural Networks Dream Visual Illusions?

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Summary: When convolutional neural networks are trained under experimental conditions, they are deceived by the brightness and color of a visual image in similar ways to...

Eric Kandel’s 10 practical tips for success in neuroscience – The Neurology Lounge

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Eric Kandel is, without a doubt, one of the finest intellects in neuroscience… And surely one of the most cheerful! A worthy Nobel Prize winner, his...

Society for Neuroscience Chapter Conference – Abstract Submission! » Department of Neurology » College...

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Poster abstracts now being accepted! We would like to invite poster abstracts for review and/or presentation at the 11th annual chapter conference on February 19th, 2021! Use this link...

Why an Early Start Is Key to Developing Musical Skill Later in Life

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Summary: Study supports the theory that learning to play music early in life is associated with higher levels of musical skill and achievement as adults.Source: APSAmong...

How the Brain Distinguishes Speech From Noise

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Summary: Study reports a pervasive neuromodulation system strongly influences sound processing in a key auditory region of the brain. Findings suggest acetylcholine may assist in the...

New study tests effectiveness of high-intensity exercise in slowing Parkinson’s symptoms » McKnight Brain...

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By Michelle Koidin Jaffee Dr. Malú Gámez TanseyThe University of Florida is collaborating on a new Phase 3 multisite clinical trial that will test the effectiveness of...

Effects of Sodium Oxybate on Weight in Children with Type 1 Narcolepsy

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Treatment with sodium oxybate in children with type 1 narcolepsy (NT1) is associated with weight reduction that stabilizes after 2 years of therapy, according to study...

Study Explains the Process That Exacerbates Multiple Sclerosis

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Summary: Recovery from multiple sclerosis-like symptoms in mice depends upon the ability for microglia to break down the remains of damaged cells.Source: Karolinska InstitutePeople with multiple...

Now’s the Time to Help Your Patients Quit Smoking

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Remember when we thought that lung cancer was enough to get people to quit smoking?Heart disease and stroke were soon added to the list of risks....

Why People Make Healthy Claims but Indulge in Unhealthy Behaviors

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Summary: When asked questions about sensitive behaviors, such as alcohol consumption or over-eating, people tend to respond in ways they consider socially correct while downplaying their...

Teen depression explodes along with smart phone use

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Although depression continues to rise among the population as a whole, it is rising most dramatically among teens, and smart phones may be largely to blame....

Neuroticism, Extraversion, and Other Personality Traits May Impact MS Outcomes

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Personality traits in patients with multiple sclerosis (MS) are frequently dysfunctional, as many patients with MS demonstrate less conscientiousness, extraversion, and agreeableness, and increased levels of...

Risk-Taking Linked to Particular Brain Features

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Summary: Researchers found functional and anatomical differences in the brains of people who are more likely to embark on risky behaviors.Source: University of ZurichRisky behaviors such...

High Blood Pressure in Midlife Is Linked to Increased Brain Damage in Later Life

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Summary: Higher than average blood pressure during middle age is associated with an increased risk of and more extensive brain damage in old age.Source: European Society...

The Role of Ketamine Infusion for Patients with MS-Related Fatigue

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Low dose ketamine infusion may be a safe and tolerable treatment strategy for multiple sclerosis (MS)-related fatigue, according to study results published in Multiple Sclerosis Journal. Chronic...

New Treatment Recommendations for Myasthenia Gravis

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A panel of international myasthenia gravis (MG) experts provided new evidence-based recommendations for the management of MG, including updated guidance for thymectomy and medical treatment. The...

Sleep Disturbance in Adolescence Associated With Opioid Misuse in Adulthood

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Sleep deficiency in adolescence may be an independent risk factor for the development of prescription opioid misuse, according to results of a study published in Sleep....

10 more catchy titles from the recent neurology literature – The Neurology Lounge

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Multiple sclerosis enters a grey area The idea that multiple sclerosis (MS), the quintessential white matter brain disease, is also a grey matter disease, is a bit...

Researchers Look to Building Better Prediction Model for Episodic Migraine Attacks

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A multivariable predictive model including self-prediction and common migraine trigger factors was only slightly better than random for predicting episodic migraine attacks, suggesting that more work...

Late-Onset Epilepsy Associated With Increased Risk for Subsequent Stroke

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People who are diagnosed with late-onset epilepsy (LOE) at age 30 years or older have a significantly increased risk for future stroke, a study in Epilepsy...

Transcranial Magnetic Stimulation Feasible for Functional Limb Weakness

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Supramotor threshold transcranial magnetic stimulation (TMS) to primary motor cortex (M1) is a safe, acceptable, efficient, and potentially effective treatment option for functional limb weakness, according...

Leuprolide Acetate: Potential Treatment for Alzheimer Disease in Women

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In the United States, Alzheimer disease (AD) is among the top 10 leading causes of mortality. In 2014, approximately 5 million Americans had AD, a statistic...

Researchers Link Poor Memory to Attention Lapses and Media Multitasking

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Summary: A new study reveals a correlation between multimedia multitasking, memory loss, and difficulties in maintaining attention.Source: StanfordThe eyes may be the windows to the soul,...

Improvements in Depression Linked to Improvements in Fatigue, Pain in MS

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Reducing depressive symptoms early may result in better improvements in functional impairment related to fatigue and pain in patients with multiple sclerosis (MS), according to study...

Later High School Start Time Linked to Decreased Adolescent Migraine Frequency

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High school students with migraine report a lower headache frequency if their school starts at 8:30 am or later, a starting time recommended by the American...

The Appropriate Diagnostic Category of Sleep-Related Dissociative Disorders

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Sleep-related dissociative disorders (SRDD) should be included in the field of sleep medicine and should be represented in the parasomnias section, according to study results published...

The Bi-Directional Association Between Dementia and Epilepsy

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Epilepsy and dementia are interlinked as patients with epilepsy have a 2-fold risk of developing dementia and those with dementia are at an increased risk for...

The Role of MSLT and Polysomnography in the Diagnosis of Narcolepsy

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Multiple sleep latency test (MSLT) and polysomnography criteria may assist in distinguishing, although not clearly, patients with narcoleptic from those with non-narcoleptic central disorders of hypersomnolence...

Small Molecule Restores Muscle Strength and Boosts Endurance in Old Mice

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Summary: A single protein called 15-PGDH appears to be a master regulator of muscle function during aging. Blocking the protein in mice increased muscle strength and...

Ophthalmologists Vital in Mitigating Systemic Risks for Patients With Diabetic Retinopathy

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Ophthalmologists play an essential role in mitigating cardiovascular and cerebrovascular risks associated with moderate to severe nonproliferative and proliferative diabetic retinopathy, according to research published in...

Significant Negative Association Between Educational Attainment and Depression Among Children

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Lower educational attainment among children and adolescents was associated with symptoms of depression. These findings, from a systematic review and meta-analysis, were published in the Journal...

COVID-19: What Now, What’s Next?

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The United States, with over 11.5 million confirmed cases of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and over 250,000 deaths, currently holds the...

Sustained Benefit of Ocrelizumab Treatment for Primary Progressive MS

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Long-term follow-up from the phase 3 ORATORIO extension study (ClinicalTrials.gov Identifier: NCT01194570) provided evidence of a consistent, long-term benefit of early and continuous ocrelizumab treatment on...

New Test for Diagnosis of Tuberculosis Meningitis in Patients With HIV

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A new 60-minute point-of-care lateral flow assay featured the same sensitivity as mycobacterial culture in detecting tuberculosis meningitis (TBM) in adult patients with HIV, according to...

Rural Medicare Beneficiaries With AD Survive Less Than Urban Counterparts

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Medicare beneficiaries with Alzheimer disease and related dementia (ADRD) who live in rural areas have shorter survival and spend more time in nursing homes, less time...

Clinical Utility of Neuromodulation for Migraine Prevention and Treatment

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According to a systematic review and meta-analysis, some neuromodulation methods appear to effectively treat symptoms of migraine; however, few studies of robust quality have been published....

Mobile Interventional Stroke Team Results in Better Early Outcomes in ELVO Stroke

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A Mobile Interventional Stroke Team (MIST) was associated with significantly faster initial door-to-recanalization times and improved clinical outcomes compared with a standard drip-and-ship (DS) model, according...

How Does the Brain Flexibly Process Complex Information?

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Summary: Researchers identify the mechanisms that support the brain’s ability to adapt the way it processes information depending upon the environment we are in.Source: Max Planck...

The Existence of the Social Brain as a Separate System

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Summary: Researchers say during group problem-solving tasks, components of the “social brain” are co-activated, but they do not increase their coupling during cooperation as would be...

COVID-19 Emerging as a Multi-Organ Disease Requiring Multidisciplinary Care

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It is now evident that COVID-19 is not simply an illness of the pulmonary system, but a disease that can have a long-lasting impact on organ...

Your antacid may be doing more harm than good

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No one can be blamed for wanting relief, especially when acid reflux makes it feel like molten lava is shooting up through your esophagus. Antacids can...

Identifying Cells to Better Understand Healthy and Diseased Behavior

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Summary: Using a range of tools from machine learning to graphical models, researchers have discovered a new way to identify cells and explore the mechanisms behind...

Myelin Loss Is a Major Factor in Age-Related Brain Deterioration

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Summary: Cells that drive myelin repair become less efficient due to aging. Myelin loss results in cognitive decline and is central to a number of neurodegenerative...

A short history of WESAN – The Neurology Lounge

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This is a follow up to my last blog post titled What has the Exeter neurology course accomplished in the last decade? There I discussed the achievements of the West...

Eye Exam Could Lead to Early Parkinson’s Disease Diagnosis

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OAK BROOK, Ill. — A simple eye exam combined with powerful artificial intelligence (AI) machine learning technology could provide early detection...

Brain Signals Decoded to Determine What a Person Sees

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Summary: Detecting and decoding activity in brain regions associated with visual processing allowed researchers to determine what a person sees.Source: WUSTLSome people are trapped within their...

Nonarteritic, Anterior Ischemic Optic Neuropathy: A Case Study

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A 62-year-old Asian man presents to the emergency department with a complaint of sudden visual impairment of his left eye for the past 5 days. The...

Total Cholesterol May Influence Cardiovascular Risk in Patients With Migraine

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Patients with migraine may have higher total cholesterol (TC) and triglyceride (TG) concentrations than healthy patients with comparable body mass index (BMI) values, according to study...

Technology Has Broken Healthcare Barriers During the COVID-19 Pandemic

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COVID-19 has prompted clinicians to change how they deliver care and to reallocate resources toward the most urgent needs on a global scale.1 Patients with diseases...

Low self-worth and no motivation? Check your dopamine

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When a person has low self-esteem, low motivation, feelings of hopelessness and worthlessness, and is prone to temperamental outbursts, it’s common to pin that on some...

How We Learn Words and Sentences at the Same Time

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Summary: Adults use similar neural mechanisms to learn novel languages as children do when learning how to process language.Source: University of LancasterHow people work out the...

How to retire a neurology blog – The Neurology Lounge

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The blogosphere is a stage; you act your part and then shuffle off the digital coil. Over the last five years, I have used...

Q&A: How to Optimize for a More Professional Telemedicine Visit

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The rapid expansion of telemedicine fueled by the COVID-19 pandemic has left many doctors scrambling to carve out impromptu office spaces in their homes.Bringing patients virtually...

Switching From Injectable to Oral Therapy for Relapsing-Remitting MS

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Switching from injectable platform therapies to the oral first-line therapies dimethyl fumarate (DMF) or teriflunomide (TFL) did not increase the risk of Expanded Disability Status Scale...

Mean or Nice? These Traits Could Make or Break a Child’s Friendships

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Summary: One child’s behavioral traits drive another child’s friendship experience over time. Children with mean friends report an increase in friendship negativity over time, while those...

Why Our Movement Disorders Specialists Love Botulinum

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When you hear the word Botox, we know what you’re thinking. In the public...

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple...

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Multiple system atrophy (MSA) is an insidious middle age-onset neurodegenerative disease that clinically presents with variable degrees of parkinsonism and cerebellar ataxia. The pathological hallmark of...

Study Examines Religious Experiences and Depression

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Summary: While attending religious services is generally associated with improvements in mental wellbeing, a new study reports spiritual experiences and belief in divine leading can lead...

Early Signs of Multiple Sclerosis

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By: Dr. Ellen Edgar  -  no responses  -  Multiple SclerosisMultiple sclerosis (MS) is a progressively disabling neurological disease affecting the central nervous system. MS is an autoimmune disease. Permanent damage...

AS03-Adjuvanted Flu Vaccine Increases Narcolepsy Incidence, Clinically Similar to Sporadic Cases

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Immunization with the AS03-adjuvanted H1N1 influenza vaccine was associated with an increased incidence of narcolepsy, but narcolepsy associated with vaccination had similar clinical features as sporadic...

Signals From Muscle Protect From Dementia

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Summary: Mimicking a muscular stress system can provide neuroprotection against aging in both the brain and retina. The signal helps prevent the buildup of misfolded protein...

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