Did Neurotoxins Cause the Salem Witch Trials?

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In the fall of 1691, crop failures in Salem Village, Massachusetts, forced residents to switch from making wheat bread to rye bread.By 1693, 175 people had...

Investigational Alzheimer’s Drug Improves Biomarkers of the Disease

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Summary: Gantenerumab, an investigational drug for Alzheimer’s disease, reduced amyloid plaques and lowered tau levels in the brains of people with genetic risk factors for the...

Timely Endovascular Thrombectomy Imperative for Favorable Post-Stroke Outcomes

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Among patients with acute ischemic stroke, every 1 second delay in endovascular thrombectomy (EVT) treatment success is associated with a 2.4-hour loss of healthy life, according...

Pregnant Women With Migraine at Higher Risk of Complications

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Summary: Pregnant women with a history of migraines are at greater risk of both prenatal and postnatal complications. A new study found migraine sufferers are at...

Predicting Recovery of Patients With Post-Traumatic Trigeminal Neuropathy

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Subjective well-being may be a contributing factor for neurosensory recovery following post-traumatic trigeminal neuropathy (PTN). These findings from a prospective observational study were published in The...

Details Behind the Body’s Response to Stress Revealed

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Summary: Study reveals how key proteins regulate the brain’s response to stress in the hippocampus.Source: McLean HospitalThe biological mechanisms behind stress-related psychiatric conditions, including major depressive...

The 130 manifestations of hereditary spastic paraparesis – The Neurology Lounge

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The hereditary spastic paraplegias (HSP) are a diverse group of inherited disorders of the spinal cord. They may be transmitted dominantly or recessively, and through...

Commentary: Neurologists on Palliative Care Communication

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Among the most powerful instruments of healing are patients’ relationships with their doctors or clinicians. Feeling seen and valued by the clinicians they trust helps patients...

Pediatric ADHD Treatment & Medication

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By: Dr. Ellen Edgar  -  no responses  -  Neurological BlogAttention Deficit Hyperactivity Disorder, also known as ADHD, is a neurodevelopmental disorder found in children who have difficulty paying attention or...

Stress During Pandemic Linked to Poor Sleep

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Summary: A new study sheds light on how COVID-19 has impacted sleep and mental health. Researchers found 32.9% of people reported a decrease in sleep and...

Childhood TBI Causes Widespread and Persistent White Matter Disruption

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Following moderate to severe traumatic brain injury (msTBI) in children, white matter disruption was widespread, persistent, and impacted by demographic and clinical factors, according to study...

Congratulations to the Neurology Diversity and Inclusion Council! » Department of Neurology » College...

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Our Neurology Diversity and Inclusion Council’s accomplishments and initiatives were selected as a finalist for the GME IDEA (Inclusion, Diversity, Equity and Access) Champion Award. The award...

P-Glycoprotein Removes Alzheimer’s-Associated Toxin From the Brain

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Summary: P-glycoprotein, a critical toxin pump in the body, has the ability to remove amyloid plaques from the brain. Researchers say increasing P-gp in the blood-brain...

Post-Traumatic Coma Prognosis is Difficult to Predict

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Although favorable outcomes are possible among young patients with post-traumatic coma, even following prolonged coma and in the presence of radiographic evidence of brainstem injury, it...

New Treatment Stops Progression of Alzheimer’s Disease in Monkey Brains

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Summary: Elderly monkeys treated with CpG ODN had 59% fewer deposits of Alzheimer’s related plaques in their brains compared to those who did not receive the...

Essential Tremor: Implications in Heterogeneous Motor Phenomenology

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Essential tremor may present with co-occurrence of other neurological disorders in the same individual or in multiple individuals in the same family; this may result in...

Speech Droplets Drive Transmission of COVID-19

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Summary: Speaking without a facemask in confined spaces poses the biggest risk for spreading SARS_CoV_2, the virus responsible for COVID-19.Source: WileyA new review published in the Journal...

Screening for Obstructive Sleep Apnea in Patients With MS

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The STOP-Bang Questionnaire may be an effective tool in screening patients with multiple sclerosis for moderate to severe obstructive sleep apnea (OSA), although the questionnaire may...

How One Neurologist Recommends Treating Sialorrhea

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You can’t underestimate the social embarrassment and hygienic issues associated with sialorrhea, or uncontrolled drooling.The condition, however, is now highly treatable — and without the side...

Aphantasia Explained: Some People Can’t Form Mental Pictures

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Summary: Aphantasia is marked by the inability to generate visual images in the mind’s eye. Researchers explore the neurobiological basis for the disorder.Source: The ConversationHow many...

HIPAA Needs to Keep Up With Information Technology

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Major updates with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule are expected in the coming months, and many stakeholders are hoping for some...

‘My Life Flashed Before My Eyes’: Researchers Explore the Phenomenon

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Summary: Following a potentially life-threatening event, people often report seeing their “lives flashing before their eyes”, where a multitude of memories from life events are recalled...

The classical disorders of the 12 cranial nerves and their checklists – The Neurology...

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Nothing depicts the strange mix of beauty and complexity of the brain as the 12 pairs of cranial nerves. These nerves take off from the three sections...

Epilepsy Seizures: 3 Summer Safety Tips to Share With Your Patients

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With the arrival of summer, and as states move to open up, chances are some of your patients are planning a little well-earned fun in the...

Clinical trial design » Department of Neurology » College of Medicine » University of...

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Congratulations to Drs. Foote and Okun on the publication of “Double blind randomized controlled trial of deep brain stimulation for obsessive-compulsive disorder: Clinical trial design,” in...

Vitamin D Deficiency May Increase Risk for Addiction to Opioids and Ultraviolet Rays

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Summary: Animal studies and analysis of human data reveal a link between vitamin D deficiency and an increased risk of both opioid addiction and sun-seeking behaviors.Source:...

Genetic Variants Linked to Lacunar Stroke and White Matter Hyperintensity

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A dozen loci were found to be associated with lacunar stroke during a pooled genome-wide association study (GWAS), according to study results published in The Lancet...

Seven Tips about Depression, Anxiety Relief, Panic Attack

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By: Dr. Ellen Edgar  -  no responses  -  Anxiety Disorder, Depression, Depression, Anxiety Disorder, & Panic Attack, Neurological BlogAt present, the world is seeing a sharp rise in the number...

Comparative pharmacovigilance assessment of mortality with pimavanserin in Parkinson disease-related psychosis » Department of...

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Congratulations to Drs. Malaty, Okun and Armstrong on the publication of “Comparative pharmacovigilance assessment of mortality with pimavanserin in Parkinson disease-related psychosis,” in the Journal of...

Unmedicated, Untreated Brain Illness Is Likely in Mass Shooters

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Summary: A new analysis of medical evidence of domestic mass shooters in the US reveals the majority of those who commit mass shootings have underlying and...

Neutrophil-to-Lymphocyte Ratio as a Prognostic Tool in IVT-Treated Ischemic Stroke

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Among patients with acute ischemic stroke undergoing intravenous thrombolysis (IVT), a high neutrophil-to-lymphocyte ratio (NLR) may predict hemorrhagic transformation as well as poor 3-month functional outcomes,...

People Who Have Trouble Sleeping Are at a Higher Risk of Dying, Especially Diabetics

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Summary: Sleep disruptions have been linked to a higher risk of death, especially in those with type 2 diabetes. Researchers found those with type 2 diabetes...

The Longitudinal Progression of Symptoms in Friedreich Ataxia

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Researchers assessed the progression of symptoms among patients with Friedreich ataxia during a prospective, observational cohort study. Their results, published in Lancet Neurology, may help inform...

New Drug to Halt Dementia After Multiple Head Injuries

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Summary: Blocking substance P following a head injury can prevent tau protein tangles from forming in the brain and lower the risk for CTE and other...

Preeclampsia May Be a Risk Factor for Later-Life Stroke

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After adjusting for time-varying covariates, preeclampsia may be an independent risk factor for later-life stroke in women who have had 1 or more pregnancies, according to...

Functional Brain Network Predicts Real-Life Social Network in Both Individuals With Schizophrenia and Social...

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Summary: Patients with schizophrenia, but not those with social anhedonia, exhibited deficits in real-life social network size. Those with schizophrenia and those with social anhedonia had...

Predicting Neurologic Recovery After Cardiac Arrest With MRI Data

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Brain magnetic resonance imaging (MRI) data may improve the prediction of neurologic recovery after cardiac arrest (CA), according to study findings published in Neurology. Study researchers in...

Gut Bacteria Connected to How Babies Experience Fear

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Summary: Study reveals a significant association between an infant’s gut microbiome and their fear response.Source: Michigan State UniversityWhy do some babies react to perceived danger more...

The A-Z of limb girdle muscular dystrophy (LGMD) – The Neurology Lounge

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The muscular dystrophies are important inherited disorders of muscle. They are characterised by their sheer diversity, their multifaceted presentations, and their complicated diagnostic pathways. By...

Sustained Long-Term Efficacy of Cladribine in Multiple Sclerosis

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Cladribine shows durable efficacy for reducing frequency and severity of relapses in patients with relapsing-remitting multiple sclerosis, according to study results published in Multiple Sclerosis Journal. Treatment...

Getting Back to Sleep – Neurology Insights

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The stress on healthcare workers over the last year and a half has been unprecedented, and it is affecting their sleep. In fact, a recent study...

Intense Teen Romances May Predict High Blood Pressure Later in Life

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Summary: Teens who find themselves in intense, controlling relationships, where they are denied healthy external friendships and self-discovery, have a higher risk for high blood pressure...

Addressing Sleep Disturbances of Parkinson Disease

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Among the various nonmotor symptoms affecting patients with Parkinson disease (PD), sleep disturbances are estimated to affect 40% to 90% of this population, and a study...

Who’s More Susceptible to Believing Falsehoods?

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Summary: Study reveals conservatives are less able to distinguish political truths from falsehoods, and the glut of right-wing media organizations producing politically incorrect content is likely...

Vitamin-Responsive Neurogenetic Diseases: Role in Disease, Tests, and Future Directions

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Vitamin-responsive inherited diseases are a rare set of conditions that may be underdiagnosed in adults. In a recent review article published in JAMA Neurology, researchers outlined...

Anyone Can Get Super-Hearing – Neuroscience News

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Summary: A new audio technique allows people to hear ultrasonic sounds at frequencies above 20,000 Hz and simultaneously perceive the direction the noise is coming from.Source:...

Brain Injury Biomarkers Associated With Outcomes of Premature Infants

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High levels of neurofilament light (NfL), a brain injury biomarker, during the first weeks of postnatal life are associated with retinopathy of prematurity (ROP) and Bayley...

Junk Food Game Helps People Eat Less and Lose Weight

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Summary: A new brain training app helps people to make healthier food choices and assists in weight-loss regimes, a new study reports.Source: University of ExeterUsing a...

Neurologic and Psychiatric Symptoms Common in COVID-19 Survivors

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Neurologic and psychiatric complaints are common in the 6 months following the diagnosis of COVID-19, with the highest risk among patients who had severe COVID-19, according...

Low Levels of Omega-3 Associated With Higher Risk of Psychosis

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Summary: Adolescents with higher levels of Omega-3 fatty acids in their blood had a decreased risk of developing psychosis as they entered into early adulthood. At...

Study: Pfizer, AstraZeneca COVID-19 Vaccines Effective Against Indian Variant

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HealthDay News — Two doses of the Pfizer and AstraZeneca COVID-19 vaccines are effective against the coronavirus variant first identified in India, according to a new report...

‘You’re Doing Great’: Preparing NDTs for Their Hardest Cases

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As the mother of a child with epilepsy, EEG tech Anna-Marie Beck knows the importance of professionalism in patient care.Patients and their families have to come...

Sometimes, Even 3-Year-Olds Just Want to Fit In With the Group

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Summary: By the age of three, children are more likely to go along with what peers say in order to follow the crowd, rather than acting...

Dexmedetomidine Oral Film Under Review for Agitation With Schizophrenia, Bipolar Disorder

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The Food and Drug Administration (FDA) has accepted for filing the New Drug Application (NDA) for BXCL501 (dexmedetomidine) for the acute treatment of agitation associated with...

Depressive Symptoms Linked to Rapid Kidney Function Decline

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Summary: More frequent symptoms of depression were linked to a rapid decline in kidney function over four years in those who initially had healthy kidney function.Source:...

The 52 variants of CMT… and their practical checklists – The Neurology Lounge

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Jean-Marie Charcot, Pierre Marie, and Howard Henry Tooth will be confounded to see what has become of the disease they described hundreds of years ago. Charcot-Marie...

Apitegromab Fast Tracked for Spinal Muscular Atrophy

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The Food and Drug Administration (FDA) has granted Fast Track designation to apitegromab for the treatment of patients with spinal muscular atrophy (SMA). Apitegromab is a selective...

Evidence for New Type of Memory

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Summary: New research indicates the existence of an unconscious iconic memory store that supports predictions made by the global workspace theory of consciousness. It also shows...

Meningeal Lymphatic Drainage May Help Improve Alzheimer Disease Outcomes

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Modulation of meningeal lymphatic function may positively influence the outcome of immunotherapy for Alzheimer disease (AD), according to a recent study. Passive immunotherapy is emerging as...

Changes in How Cholesterol Breaks Down in the Body May Accelerate Progression of Dementia

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Summary: Disruptions in how the body converts cholesterol into bile acids may play a key role in the development of dementia.Source: PLOSThe blood-brain barrier is impermeable...

Exploring the Biomarker Modalities of Migraines

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In diagnosing migraine based on clinical criteria, neurologists may overlook genetic and neurobiological factors. Study researchers presented the latest findings on biomarker modalities for migraines and...

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple...

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Multiple system atrophy (MSA) is an insidious middle age-onset neurodegenerative disease that clinically presents with variable degrees of parkinsonism and cerebellar ataxia. The pathological hallmark of...

Impaired Dopamine Transporters Contribute to Parkinson’s Disease-Like Symptoms

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Summary: A rare genetic mutation interferes with dopamine transporters in the brain, causing Parkinson’s-like symptoms in children.Source: eLifeA rare mutation that causes Parkinson’s disease-like symptoms interrupts...

Novel Calcium Regulation Gene Identified as Having Causal Role in Chronic Widespread Musculoskeletal Pain

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A locus involved with calcium regulation was associated with chronic widespread musculoskeletal pain (CWP). These findings were published in the Annals of the Rheumatic Diseases. For this...

Simple Diagnostic Tool Predicts Individual Risk of Alzheimer’s

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Summary: A new algorithm that uses data from memory tests and blood samples is able to accurately predict an individual’s risk for developing Alzheimer’s disease.Source: Lund...

Tilavonemab Not Effective in Progressive Supranuclear Palsy

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Among patients with progressive supranuclear palsy (PSP), treatment with tilavonemab did not affect progression of the disorder and the phase 2 study was terminated after a...

Childhood Disadvantage Affects Brain Connectivity

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Summary: Functional connectivity was reduced within and between several brain networks in children raised in disadvantaged neighborhoods. Researchers say a positive home and school environment can...

Early Coagulopathy Increases Mortality Risk in Children With TBI

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Early coagulopathy increases the risk of mortality and poor functional outcomes in both adults and children with traumatic brain injury (TBI), according to study results published...

Easy and Practical Steps to Make Your Office More Welcoming

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In last week’s post we talked about how the American Academy of Neurology has taken a hard stance against racism and other systemic inequities.The organization is...

Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation » Department of...

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Congratulations to Drs. Takashi Tsuboi, Joshua K Wong, Robert S Eisinger, Mathew R Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D Foote, and Michael S Okun on the publication of “Comparative...

Overcoming Long-Term Trauma Can Be Facilitated

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Summary: Researchers facilitated the extinction of long-term traumatic memories in mice by enhancing activity in the nucleus reuniens.Source: EPFLHow the brain deals with trauma is complex,...

Accelerated Neuromuscular Aging: Effect of Type 1 Diabetes on Muscle Function and Morphology

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As patients with type 1 diabetes (T1D) age, earlier onset of muscle weakness and fatigue can contribute to increasing frailty, muscle atrophy, and diminished muscle function,...

Mapping autonomic, mood, and cognitive effects of hypothalamic region deep brain stimulation » Department...

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Congratulations to Drs. Wissam Deeb, Leonardo Almeida, Kelly D Foote, and Michael S Okun on the publication of “Mapping autonomic, mood, and cognitive effects of hypothalamic region deep...

‘Sounding It Out’ Not so Easy for Children With Dyslexia

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Summary: Neuroimaging study reveals a biological deficit in some children with dyslexia that impairs phonological decoding.Source: University of Western OntarioFor years, competent and well-educated elementary school...

The Power of Touch: How Physical Contact Can Reshape the Clinical Exam ─ Part...

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This is Part 2 of a 2-part series related to the power of touch in the clinical medical environment. In Part 1, we review the history and...

Why Do We Hate the Sound of Our Own Voices?

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Summary: The discomfort we feel when hearing our own voices played back to us is both a physiological and psychological response, researchers say.Source: The ConversationAs a...

5 Ways Stress and Depression Can Affect Epilepsy

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Patients’ conditions can significantly affect their quality of life in many ways. Medical professionals should be aware of how these conditions can affect patients’ mental health....

Alzheimer Protein App Regulates Learning and Social Behavior in the Healthy Brain

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Summary: APP, a protein commonly associated with Alzheimer’s disease, plays a vital role in learning, memory, and social behavior in the developing brain, a new mouse...

Atorvastatin With Sodium Valproate Can Reduce Migraine Attacks and Pain Severity

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Adding atorvastatin to treatment with sodium valproate may reduce the number of acute migraine attacks and pain severity in patients with migraine with aura, according to...

Mutation Linked to Autism Impairs Oxytocin-Mediated Social Behavior

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Summary: A genetic mutation of Caps2 impairs the release of oxytocin, leading to problems in regulating social behavior in those on the autism spectrum.Source: Tokyo University...

Global Decline in Stroke and IV Thrombolysis Hospitalizations Early in COVID-19 Pandemic

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A global trend of fewer hospital admissions for stroke and intravenous thrombolysis (IVT) was observed early in the COVID-19 pandemic, according to results of a cross-sectional,...

Linguistic and Biological Diversity Linked

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Summary: Cultural, linguistic, and biological diversity are linked, researchers say. The link may be to preserve both natural environments and indigenous populations.Source: Penn StateCultural diversity —...

Combination Immunotherapy Effective for Patients With Melanoma and Asymptomatic Brain Metastases

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The combination of nivolumab with ipilimumab is an effective treatment option for patients with advanced melanoma with asymptomatic brain metastases and should be considered for first...

Yoga and Breathing Exercises Aid Children With ADHD to Focus

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Summary: Yoga and breathing training programs can help children with ADHD to focus their attention, a new study reports.Source: Ural Federal UniversityYoga and breathing exercises have...

Increased Risk for CVST With Thrombocytopenia in J&J COVID-19 Vaccine Recipients

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During March 2 to April 21, 2021, there were 12 cases of cerebral venous sinus thrombosis (CVST) with thrombocytopenia reported after receipt of the Ad26.COV2.S (Janssen/Johnson...

Children Likely to Be Pleading Guilty When Innocent

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Summary: Young people are more susceptible to pleading guilty to a crime, even though they are innocent. Researchers say the differences in children’s brains which affect...

30 essential anti-epilepsy drugs and their practical checklists – The Neurology Lounge

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Epilepsy is a big problem for Neurology. It is a common, and often life-long, disease. Epilepsy is like the mythical hydra – both in its diverse...

The Power of Touch: How Physical Contact Can Reshape the Clinical Exam — Part...

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This is Part 1 of a 2-part series on the power of touch in the clinical medical environment. In Part 2, we will resume our interview with...

Food Dyes May Cause Disease When the Immune System Is Dysregulated

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Summary: Mice with cytokine IL-23 dysregulation who consumed foods containing the artificial colorants FD&C Red 40 and Yellow developed colitis, a new study reports.Source: Mount Sinai...

A Call for Action Against Racism in Patient Care

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Alienation of minority patients and labeling and generalization about their lower socioeconomic class, lifestyle practices, and needs result in inadequate treatment, suggesting that racial bias in...

AAN Focuses on Equity, Diversity and Inclusion at Annual Meeting

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Healthcare inequities were front and center at the most recent annual meeting of the American Academy of Neurology (AAN), which included a Health Care Equity Symposium...

Virginia Tech Launches ‘Next Generation’ Human Brain Imaging Lab

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Summary: Virginia Tech researchers have received a grant to deploy a new brain imaging technology called optically pumped magnetometry which can assist with studying the nuances...

Clues to Memory Impairment in Cerebral Amyloid Angiopathy

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Among patients with cerebral amyloid angiopathy (CAA), the presence of memory impairment may serve as a marker of tau pathology and medial temporal lobe integrity, according...

Tumor-Promoting Immune Cells Retrained to Fight Most Aggressive Type of Brain Cancer

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Summary: Combining αGITR antibodies with ICBs resulted in stronger survival benefits in mouse models of human glioblastoma brain cancer.Source: Mass GeneralIt’s a real-life plot worthy of...

Novel, Rare Variants Associated With Alzheimer Disease and Replicated in an Independent Cohort

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Thirteen new rare candidate loci associated with Alzheimer disease (AD) were identified. These findings were published in Alzheimer’s and Dementia. Whole genome sequencing was performed among 2247...

Intoxication Brings Strangers Physically Closer

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Summary: Strangers who drink together start off at a distance, but move closer together as they become more intoxicated, a new study reports.Source: University of IllinoisIn...

Increased Stroke Risk in Younger Adults During the Convalescent Phase of COVID-19

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Younger adults with asymptomatic or minimally symptomatic COVID-19 are at an increased risk for acute ischemic stroke (AIS) during the convalescent phase of the infection, according...

Researchers Develop Artificial Intelligence That Can Detect Sarcasm in Social Media

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Summary: A newly developed artificial intelligence algorithm can accurately detect sarcasm in comments written on social media platforms.Source: University of Central FloridaComputer science researchers at the...

Pulse Rate Variability May Predict Stroke in Obstructive Sleep Apnea

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Pulse rate variability as detected by pulse oximetry could serve as a useful biomarker for stroke risk stratification in patients with obstructive sleep apnea (OSA), according...

New MRI Technique Can Detect Early Dysfunction of the Blood-Brain Barrier With Small Vessel...

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Summary: DP-ASL, a new neuroimaging technique may help researchers identify early blood-brain barrier dysfunction associated with SVD.Source: University of KentuckyCollaborative research between the University of Kentucky...

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