An Alternative Hypothesis of Alzheimer’s Based on Synaptic Alterations

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Summary: Amyloid precursor protein accumulated with an excess of presynaptic proteins, whereas post synaptic proteins were depleted.Source: Wyss Center for Bio and NeuroengineeringNew research published today...

Neuroimaging in Multiple Sclerosis: Predicting Longitudinal Disability and Cognition

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Brain imaging findings may offer predictive value for long-term disability progression and cognitive decline in patients with multiple sclerosis (MS), according to findings from a meta-analysis...

Men Who Worry More May Develop Heart Disease and Diabetes Risk Factors at Younger...

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Summary: Middle-aged men who worry more or display traits associated with neuroticism are at greater biological risk for cardiovascular disease, stroke, and type 2 diabetes as...

Amyotrophic Lateral Sclerosis Cognitive Profiles: Levels of Insight Into Behavioral Changes

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Patients with amyotrophic lateral sclerosis (ALS) but without dementia had behavioral declines and retained varying levels of insight into this decline, while premorbid verbal intelligence was...

How Robots Learn to Hike

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Summary: A newly developed control technology that combines proprioception with visual perception allows robots to tackle rough terrains faster and more efficiently.Source: ETH ZurichSteep sections on...

Increased Opioid Prescribing Observed During the COVID-19 Pandemic

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A retrospective, observational, cross-sectional study found that early in the COVID-19 pandemic, there was increased opioid prescriptions and that prescription durations were longer with higher doses...

Cholesterol Buildup in Brain Presents New Target to Reduce Dementia Risk From Stroke

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Summary: Cyclodextrin, an FDA-approved drug, reduced cholesterol accumulation from broken down brain cells and inflammation in animal models. The findings point to a potential new therapy...

Dementia Risk Lower in Older Adults With Higher Baseline Blood Pressure Level

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Older adults with higher baseline systolic blood pressure (SBP) levels have a lower risk for incident dementia, and more distinctly U-shaped associations between SBP and dementia...

Haunted-House Experience Scares up Interesting Insights on the Body’s Reaction to Threats

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Summary: The presence of friends increases arousal when people are exposed to scary stimuli, researchers report. Additionally, the stronger the response to the initial stimuli, the...

When and How to Shift Workers’ Gears

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In the United States, 20% of employees work during shifts that are outside of the traditional 9:00 AM to 5:00 PM schedule, including many in the health...

Old Neurons Can Block Neurogenesis in Mice

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Summary: Hippocampal neurogenesis and cognitive function were improved in aging mice by destroying senescent cells in the aging stem cell niche.Source: Cell PressDestroying senescent cells in...

Lifestyle Factors, Comorbidities Influence Cognition in Early Parkinson Disease

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A cross-sectional study found potentially modifiable comorbidities and lifestyle factors which may contribute to the cognitive profile of patients with early Parkinson disease (PD). These findings...

Understanding Memory Loss in Alzheimer’s Disease

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Summary: Findings reveal the accumulation of the synaptic protein neurexin may be a cause of memory loss associated with Alzheimer’s disease.Source: University of SevilleMembers of the...

Prolonged COVID-19 Symptoms Prevalent in Patients With Multiple Sclerosis

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 Nearly a third of patients with multiple sclerosis (MS) who recovered from COVID-19 experienced postacute sequelae, according to findings from a prospective and longitudinal cohort study...

Emotional and Neuropsychiatric Disorders Associated with Alzheimer’s Disease » Department of Neurology » College...

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Congratulations Drs. Heilman and Nadeau on the publication of your article, Emotional and Neuropsychiatric Disorders Associated with Alzheimer’s Disease.  This was published in the January issue...

How We Understand Causality – Neuroscience News

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Summary: A new study considers how people acquire and utilize knowledge about causal relationships.Source: University of GöttingenHow people acquire and use knowledge about causal relationships is...

Short-Term DAPT With Aspirin and Ticagrelor, Clopidogrel May Reduce Stroke Risk

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Dual antiplatelet therapy (DAPT) with aspirin and either ticagrelor or clopidogrel was superior to aspirin alone for preventing recurrent strokes or death up to 90 days,...

How Neurodiagnostic Techs Are Doing Navigating COVID-19

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Kevin Helm’s first year and a half with ASET was interesting — to say the least.Helm was announced as the new executive director of ASET –...

Harnessing the Brain’s Plasticity to Acquire Epilepsy Resilience

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Summary: Optogentic stimulation has the potential to cultivate resilience to epileptic seizures in animal models, researchers report.Source: Tohoku UniversityAround 1 percent of the world’s population lives...

Sleep Deprivation Affects Emotion Regulation, But Not Processing

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Study data published in PLoS One describe the potential effects of sleep deprivation on emotion regulation. In a cohort of healthy adults exposed to sleep deprivation,...

New Theory Proposes Forgetting Is Actually a Form of Learning

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Summary: Researchers propose forgetting memories or things we have learned may be a functional feature in the brain and actually an additional form of learning.Source: TCDWe...

Worse Visual Outcomes After Stroke Associated With Age

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Among patients with stroke, older individuals had poor slow binocular and slow and fast monocular vergence. These findings, from a prospective study, were published in the...

The Free-Energy Principle Explains the Brain

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Summary: The free-energy principle can explain how neural networks minimize energy costs and are optimized for efficiency.Source: RIKENThe RIKEN Center for Brain Science (CBS) in Japan,...

COVID-19 Hospitalization Not Tied to Rituximab Timing, Dose in Patients With MS

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Among patients with multiple sclerosis (MS) who received rituximab before being diagnosed with COVID-19, no statistically significant association was observed between the timing of rituximab infusion...

Symptoms and Traits of Borderline Personality Disorder May Run In Families

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Summary: Family members of people with borderline personality disorder share similarities in brain structure and personality traits as those diagnosed with the personality disorder. Findings may...

Identifying Factors That Influence the Risk for Mild Cognitive Impairment

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Sociodemographic factors, including years of education and income, are associated with a lower risk for MCI, while the use of antidepressants may be associated with an...

Epstein-Barr Virus May Be Leading Cause of Multiple Sclerosis

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Summary: The risk of developing mutliple sclerosis increases 32 fold following Epstein-Barr virus infection.Source: HarvardMultiple sclerosis (MS), a progressive disease that affects 2.8 million people worldwide...

Risk Factors for Lobar Intracerebral Hemorrhage and Death in Cerebral Amyloid Angiopathy

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Patients who presented with cerebral amyloid angiopathy (CAA)-associated transient focal neurological episodes (TFNEs) were found to be at increased risk for lobar intracerebral hemorrhage (ICH) and...

Remembering Faces and Names Can Be Improved During Sleep

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Summary: Deep, uninterrupted sleep can help boost learning names and faces, a new study reports.Source: Northwestern UniversityFor those who rarely forget a face, but struggle with...

Less Screen Time Postconcussion Leads to Faster Recovery for Young Adults

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An abstinence of screen time in the first 48 hours after a concussion is associated with a significantly faster recovery among patients aged 12 to 25...

Sleep Deprivation Increases Serotonin 2a Receptor Response in Brain

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Summary: Sleep deprivation increases the levels of serotonin 2A neurotransmitter receptors within 6 – 8 hours. Abnormal serotonin 2A receptor function is associated with hallucinations, cognitive...

Friedreich Ataxia Impacts Growth and Weight Gain in Adult and Pediatric Patients

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Friedreich ataxia was found to affect both weight gain and linear growth in adult and pediatric patients, according to results of a prospective natural history study,...

Years Lived Alone And / Or Serial Break-UPS Strongly Linked to Inflammation in Men

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Summary: Men who spend several years living alone or experience serial relationship breakups are at increased risk of inflammation, a new study reports.Source: BMJLiving alone for...

Loss of Balance Trends in Patients With Multiple Sclerosis and Parkinson Disease

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A loss of balance (LOB) rating scale following manual perturbations was found to be reliable and reproducible among patients with multiple sclerosis (MS) and Parkinson disease,...

Findings Open the Way to More Precise Diagnoses and Treatments of Alzheimer’s Disease

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Summary: Researchers have identified a link between misshapen, fast replicating tau proteins, and accelerated cognitive decline. The findings shed new light on the development and progression...

Global Increases in Depression, Anxiety During COVID-19 Pandemic

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Study data published in The Lancet describe the psychiatric effects of the COVID-19 pandemic on a global scale. Per a systematic review of studies conducted in...

How Do We Provide Meaning to Our Environment? Cracking the Neural Code to the...

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Summary: Study explores how a mouse brain understands sensory information, specifically the perception of touch.Source: Boston UniversityThe brain is the most complex organ in our body—constantly...

Appreciation for the journey – The Neurology Lounge

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I have only unstinting gratitude to Dr Hadi Manji to whom I owe my whole career as a neurologist in the United Kingdom. No words are...

Multiple Sclerosis and Pregnancy: Outcomes of Early Dimethyl Fumarate Exposure

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Delayed-release dimethyl fumarate (DMF) exposure in the first trimester among pregnant women with multiple sclerosis (MS) is not significantly associated with adverse pregnancy outcomes, according to...

How the Brain Helps Us Focus Our Attention

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Summary: A new framework describes how the locus coeruleus regulates the brain’s sensitivity to relevant information during situations that require attention.Source: Max Planck InstituteHow can we...

Restricting Supply Alone Is Not the Answer to the Opioid Crisis

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The current system to address the US opioid epidemic is not ideal. Policies and guidelines have focused primarily on reducing opioid prescribing and restricting supply. However,...

Passive Virtual Reality More Sickness-Inducing Than Active Play

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Summary: Study finds passively observing virtual reality games increases cybersickness, while actively participating in VR games diminishes feelings of motion sickness associated with virtual reality.Source: Mary...

Natalizumab Shows Weak Impact in Patients With Drug-Resistant Epilepsy

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Adjunctive treatment with natalizumab did not change seizure frequency in a small sample of patients with severely drug-resistant focal epilepsy, but no unexpected safety findings were...

Link Between Brain Chemical and Visual Processing in Autism

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Summary: When GABA targets are activated, visual processing for people on the autism spectrum becomes more like that of non-autistic people.Source: King’s College LondonResearchers from King’s...

The Treatment Gap in Acute Ischemic Stroke Worldwide: A Call to Improve Care

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Acute stroke care is cost-effective across the board in low- , middle-, or high-income countries; therefore, the call of the hour is to encourage a collaborative...

Babies Born During Pandemic’s First Year Score Slightly Lower on a Developmental Screening Test

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Summary: At six months of age, babies born during the first year of the COVID-19 pandemic scored lower on developmental screening tests for social and motor...

Noncontrast CT for Mechanical Thrombectomy in Extended Time Window: The Outcomes

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No difference was observed between noncontrast computed tomography (NCCT) compared with advanced imaging modalities among patients undergoing proximal anterior circulation mechanical thrombectomy in the extended time...

Researchers Predict Rat Behaviors From Brain Activity

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Summary: Distinct, coordinated activity in large sets of neurons can predict the future behaviors of rats, a new study reports. Based on the findings, researchers have...

Sleeping Mice Show Busy Brains

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Summary: Findings reveal the brain may optimize visual information processing depending on its conscious state.Source: Kyoto UniversityWhat we see in front of us is what our...

Survey Results: ADHD Comorbidities in College Students

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In a recent survey, more than half the college students with ADHD had at least 1 psychiatric disorder. The recent WHO World Mental Health Survey of...

67 brand new practical neurology checklists to welcome 2022 – The Neurology Lounge

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2022 promises to be a defining year for Neurochecklists. With one book just published, and another in the works (more on this in early 2022), I...

Factors That Contribute to Aggressive Behaviors at Inpatient Psychiatric Wards

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A systematic review found that aggression in psychiatric wards was due to a combination of patient, ward, and staff factors. These findings were published in PLOS...

10 catchy neurology headlines to bid farewell to 2021 – The Neurology Lounge

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Carrying on with my tradition of highlighting the most captivating neurology headlines, here again is a selection of 10 neurology articles with catchy titles. Each headline...

The Effect of Erythropoietin on Visual Outcomes in Optic Neuritis

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After optic neuritis, erythropoietin, a human cytokine, as an adjunct to corticosteroids did not have a neuroprotective effect on the visual pathways. These findings, from a...

Battle of the Sexes Begins in Womb as Father and Mother’s Genes Tussle Over...

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Summary: The father’s genes drive a fetus’ demand for larger blood vessels and more nutrients, while maternal genes in the placenta try to take control over...

Dabrafenib Plus Trametinib Effective for Gliomas With BRAF V600E Mutations

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Dabrafenib plus trametinib combination therapy showed clinically meaningful and durable activity in patients with recurrent or progressive BRAF V600E mutation–positive high-grade and low-grade glioma, according to...

A Common Risk Factor for Alzheimer’s Disease May Predispose Carriers to Severe COVID-19

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Summary: Carriers of the Alzheimer’s associated APOE4 gene have more than double the risk of developing severe COVID-19, a new study reports. Additionally, more microscopic hemorrhages...

Retinal Degeneration Spotted in Chronic Inflammatory Demyelinating Polyneuropathy

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Subtle retinal degeneration may be evident on optical coherence tomography (OCT) in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), providing further evidence for a central nervous...

Have You Fallen for the Myth of ‘I Can’t Draw’? Do It Anyway –...

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Summary: Researchers say whether you are a competent artist or not, drawing and doodling can have a positive effect on your mental health and can help...

Amyotrophic Lateral Sclerosis Prevention: Neurodegenerative Diseases Offer Insight

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Lessons learned from various presymptomatic neurodegenerative diseases may provide opportunities for early intervention, and perhaps even disease prevention of amyotrophic lateral sclerosis (ALS), according to a...

Is Energy the Key to Alzheimer’s Disease?

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Summary: Study identifies a link between how cells produce energy for brain function and a genetic mutation associated with Alzheimer’s disease.Source: University of AdelaideA team of...

Altered Basal Ganglia Connectivity Tied to Apathy, Motor Signs in Huntington Disease

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Changes and imbalances that occur in connectivity in the basal ganglia motor loop are associated with common motor signs as well as apathy observed in patients...

Neurons in the Olfactory Cortex Link Smells to Places

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Summary: Neurons in the primary olfactory cortex play a role in encoding spatial maps, a new study reports.Source: Champalimaud Centre for the UnknownSmell has the power...

200 inspiring neurology patient support groups – The Neurology Lounge

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Neurology is a jungle, and for the unwary, a minefield. It has one of the most diverse and complex diseases of all the medical specialties. Neurological...

Psychiatric Disorders in Adolescence Linked to Absence From School and Jobs

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Adolescents’ diagnosis with psychiatric disorders, especially psychosis and autism spectrum disorder (ASD), is associated with long term absence from education, employment, or training (“Not in Education,...

New Alzheimer’s Prevention Trial in Young People

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Summary: A new international clinical trial has been launched with an aim of preventing Alzheimer’s disease in people with a genetic disposition who are likely to...

140 extraordinarily deceptive manifestations of epilepsy – The Neurology Lounge

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Epilepsy is a very common neurological disorder, and many people feel confident they can recognise an epileptic seizure when they see one. In the popular imagination,...

Effects of Daily Intranasal Oxytocin in Patients With Autism Spectrum Disorder

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Daily intranasal oxytocin did not significantly improve social functioning in children or adolescents with autism spectrum disorder, according to results of a phase 2 trial published...

Language and Aphasias » Department of Neurology » College of Medicine » University of...

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Congratulations to Dr. Stephan Nadeau on the publication of “Language and Aphasias,” which was published in the December issue of Behavioral Neurology and Psychiatry. This article reveals...

Interesting Patterns of Brain Activity Emerge During Musical Analysis Exercises

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Summary: Study reveals a specific link between musical processing and brain areas associated with language processing.Source: University of TokyoResearchers in Japan used magnetic resonance imaging to...

Adapted Ketogenic Diet and Neuroprotective Benefits in Multiple Sclerosis

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An adapted ketogenic diet (AKD) reduced serum neurofilament light chain (sNfL) levels at 6 months in patients with relapsing-remitting multiple sclerosis (MS), according to study findings...

Ultrasound of optic nerve linings and stroke outcomes » McKnight Brain Institute » University...

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By Michelle Jaffee Drs. Rohit Patel and Michael PizziA newly published study by University of Florida physician-researchers demonstrates a noninvasive way to predict long-term outcomes among stroke...

Stigma Surrounding Depression Drops for First Time in Us, but Increases for Other Mental...

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Summary: While the stigma against depression has decreased for the first time, the stigma levels for other mental health disorders have either remained stagnant or increased.Source:...

Migraine-Diet Connection: Dietary Triggers and Interventions for Migraine Management

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Dietary intake may precipitate migraine attacks, with up to 60% of patients reporting exacerbations following consumption of specific foods and beverages. Chocolate, coffee, cheese, and alcohol...

When IONM Techs Make a Difference

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The efficacy and cost effectiveness of intraoperative neuromonitoring (IONM) can be difficult to determine.The perceived usefulness of IONM, according to Christopher Halford, the END (electroneurodiagnostic) program...

Brain Mechanisms Involved in Learning Also Drive Social Conformity

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Summary: A brain network implicated in learning by trial and error also becomes engaged when people adapt to social norms, a new study reports. Findings suggest...

EEG Identifies Clinical Subgroups Within Amyotrophic Lateral Sclerosis

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Electroencephalography (EEG) measures of neural activity and connectivity can be used to reproducibly group patients with amyotrophic lateral sclerosis (ALS) into subphenotypes with distinct clinical patterns...

What Makes an IONM Tech’s Job So Challenging?

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The technicians who perform intraoperative neuromonitoring are not there to diagnose an issue that occurs during surgery, but they must be quick at recognizing one that...

Consciousness in Humans, Animals and Artificial Intelligence

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Summary: A new theory suggests consciousness is a state tied to complex cognitive operations, and not a passive basic state that automatically prevails when we are...

Reducing Neuroimaging in Seizures With LIMIT Clinical Decision Instrument

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Compared with unstructured physician discretion, using the Let’s Image Malignancy, Intracranial Hemorrhage, and Trauma (LIMIT) clinical decision instrument (CDI) for determining which patients should undergo brain...

Are Rocket Scientists and Brain Surgeons Really Smarter Than Everyone Else?

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Summary: In terms of general intelligence, rocket scientists and brain surgeons are no smarter than the general population, researchers report.Source: BMJRocket scientists and brain surgeons are...

Increased Microscopic Brain Permeability Seen in Reversible Cerebral Vasoconstriction Syndrome

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Increased microscopic brain permeability is observed during acute stage of reversible cerebral vasoconstriction syndrome (RCVS), according to study findings published in Neurology. Furthermore, the research suggests...

Visuals Increase Attention; Now Science Explains Why

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Summary: Norepinephrine is locally regulated in the visual cortex. More norepinephrine is released when and where visual information is processed.Source: UT Health San Antonio“Look at me!”...

Legal and Ethical Approaches to a Patient’s Request for an Emotional Support Animal

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While cultural attitudes toward animals may vary, researchers note there is a “commonly held belief that pets can improve the overall quality of human life.”1 In...

Revealing How the Brain Understands One Voice in a Noisy Crowd

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Summary: Study reveals how the brain is able to focus its attention on a single speaker in a crowded, noisy environment.Source: University of RochesterIn a crowded...

The 75 most challenging neurological diagnoses – The Neurology Lounge

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Neurologists typically see run-of-the-mill disorders in their usual practice. Not to underestimate the seriousness of these syndromes, but these are not conditions that keep the neurologist...

COVID-19 Mortality Tied to Neurologic Manifestations in Older Adults

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Up to one-third of COVID-19 patients experienced at least 1 neurologic manifestation, and about 2% experienced stroke, according to a systematic review and meta-analysis published in...

How Diet Influences Taste Sensitivity and Preference

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Summary: Diet influences dopamine and insulin signaling in the brain, which in turn directly affects the peripheral sensory response in fruit flies. This response influences what...

Cerebral Palsy Pain Classification Tool May Improve Assessment, Diagnosis

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Researchers have proposed a Cerebral Palsy Pain Classification (CPPC) tool that is specific for children with CP and is based on the International Classification of Diseases,...

Learning and Protecting Itself: How the Brain Adapts

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Summary: Blocking the matrix metalloproteinases MMP2 and MMP9 can have the opposite effect on neuroplasticity depending on whether the brain is healthy or injured.Source: University of...

Long Sleep Duration and Cognitive Function: What’s the Association?

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A cross-sectional study found that sleep duration may affect episodic memory, according to study findings published in the Journal of Sleep Research. Sleep is an important component...

Common Sleep Disorder Combo Could Be Deadly

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Summary: People who suffer from insomnia in conjunction with sleep apnea are more likely to experience heart problems and are 50% more likely to die than...

Stuttering Associated With Presence of Elevated Iron in Basal Ganglia

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Patients who stutter have elevated R2* in the left putamen and connected frontal cortical regions, which likely reflects increased iron concentrations, compared with individuals who do...

Schizophrenia: Altered Brain Structural Connectivity and Association With Neurological Soft Signs

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Summary: A new study found altered cortical and subcortical networks in those with schizophrenia and their unaffected first-degree relatives. Findings suggest brain regions associated with a...

Early Data Suggest Potential Benefit of Heterologous Boosting for COVID-19

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Early data suggest a greater increase in CD8+ T-cell response when the Janssen COVID-19 vaccine (Ad26.COV2.S), a viral vector vaccine, is administered as a booster 6...

Low-Income Kids Use Different Brain Function to Ace Achievement Tests

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Summary: Children from lower socioeconomic backgrounds with stronger connectivity between the lateral frontoparietal network and default mode network performed better in educational tests than those with...

Sleep-Related Hypoxia Tied to Higher Risk for COVID-19 Hospitalizations, Death

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While sleep-disordered breathing (SDB) and sleep-related hypoxia do not increase the risk of SARS-CoV-2 infection, sleep-related hypoxia may be a risk factor for worse outcomes associated...

Human Brain Development Study Sheds Light on Neurodevelopmental Disorders

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Summary: A new investigation into interneuron development sheds light on how disorders associated with neurodevelopment, such as autism and schizophrenia may occur.Source: King’s College LondonNew research...

7 potentially curable neurological disorders – The Neurology Lounge

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Neurologists are often at the receiving end of the jokes of other medical specialists. They facetiously remark that neurologists know a lot, but do very little...

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