Summary: Study reveals specific neurons in the ventrolateral prefrontal cortex and anterior cingulate cortex that become active when people are faced with the decision to learn or hide from information about an adverse event the person is not able to prevent.

Source: WUSTL

The term “doomscrolling” describes the act of endlessly scrolling through bad news on social media and reading every worrisome tidbit that pops up, a habit that unfortunately seems to have become common during the COVID-19 pandemic.

The biology of our brains may play a role in that. Researchers at Washington University School of Medicine in St. Louis have identified specific areas and cells in the brain that become active when an individual is faced with the choice to learn or hide from information about an unwanted aversive event the individual likely has no power to prevent.

The findings, published June 11 in Neuron, could shed light on the processes underlying psychiatric conditions such as obsessive-compulsive disorder and anxiety — not to mention how all of us cope with the deluge of information that is a feature of modern life.

“People’s brains aren’t well equipped to deal with the information age,” said senior author Ilya Monosov, PhD, an associate professor of neuroscience, of neurosurgery and of biomedical engineering.

“People are constantly checking, checking, checking for news, and some of that checking is totally unhelpful. Our modern lifestyles could be resculpting the circuits in our brain that have evolved over millions of years to help us survive in an uncertain and ever-changing world.”

In 2019, studying monkeys, Monosov laboratory members J. Kael White, PhD, then a graduate student, and senior scientist Ethan S. Bromberg-Martin, PhD, identified two brain areas involved in tracking uncertainty about positively anticipated events, such as rewards. Activity in those areas drove the monkeys’ motivation to find information about good things that may happen.

But it wasn’t clear whether the same circuits were involved in seeking information about negatively anticipated events, like punishments. After all, most people want to know whether, for example, a bet on a horse race is likely to pay off big. Not so for bad news.

“In the clinic, when you give some patients the opportunity to get a genetic test to find out if they have, for example, Huntington’s disease, some people will go ahead and get the test as soon as they can, while other people will refuse to be tested until symptoms occur,” Monosov said.

“Clinicians see information-seeking behavior in some people and dread behavior in others.”

To find the neural circuits involved in deciding whether to seek information about unwelcome possibilities, first author Ahmad Jezzini, PhD, and Monosov taught two monkeys to recognize when something unpleasant might be headed their way. They trained the monkeys to recognize symbols that indicated they might be about to get an irritating puff of air to the face.

For example, the monkeys first were shown one symbol that told them a puff might be coming but with varying degrees of certainty. A few seconds after the first symbol was shown, a second symbol was shown that resolved the animals’ uncertainty. It told the monkeys that the puff was definitely coming, or it wasn’t.

The researchers measured whether the animals wanted to know what was going to happen by whether they watched for the second signal or averted their eyes or, in separate experiments, letting the monkeys choose among different symbols and their outcomes.

The findings, published June 11 in Neuron, could shed light on the processes underlying psychiatric conditions such as obsessive-compulsive disorder and anxiety — not to mention how all of us cope with the deluge of information that is a feature of modern life. Image is in the public domain

Much like people, the two monkeys had different attitudes toward bad news: One wanted to know; the other preferred not to. The difference in their attitudes toward bad news was striking because they were of like mind when it came to good news. When they were given the option of finding out whether they were about to receive something they liked — a drop of juice — they both consistently chose to find out.

“We found that attitudes toward seeking information about negative events can go both ways, even between animals that have the same attitude about positive rewarding events,” said Jezzini, who is an instructor in neuroscience. “To us, that was a sign that the two attitudes may be guided by different neural processes.”

By precisely measuring neural activity in the brain while the monkeys were faced with these choices, the researchers identified one brain area, the anterior cingulate cortex, that encodes information about attitudes toward good and bad possibilities separately.

They found a second brain area, the ventrolateral prefrontal cortex, that contains individual cells whose activity reflects the monkeys’ overall attitudes: yes for info on either good or bad possibilities vs. yes for intel on good possibilities only.

Understanding the neural circuits underlying uncertainty is a step toward better therapies for people with conditions such as anxiety and obsessive-compulsive disorder, which involve an inability to tolerate uncertainty.

“We started this study because we wanted to know how the brain encodes our desire to know what our future has in store for us,” Monosov said. “We’re living in a world our brains didn’t evolve for. The constant availability of information is a new challenge for us to deal with. I think understanding the mechanisms of information seeking is quite important for society and for mental health at a population level.”

See also

This shows a model of a head with a model of a brain inside

Co-authors Bromberg-Martin, a senior scientist in the Monosov lab, and Lucas Trambaiolli, PhD, of Harvard Medical School, participated in the analyses of neural and anatomical data to make this study possible.

About this neuroscience research news

Source: WUSTL
Contact: Judy Martin Finch – WUSTL
Image: The image is in the public domain

Original Research: Closed access.
“A prefrontal network integrates preferences for advance information about uncertain rewards and punishments” by Ilya Monosov et al. Neuron


Abstract

A prefrontal network integrates preferences for advance information about uncertain rewards and punishments

Highlights

  • Little is known about the mechanisms of information seeking about punishments
  • Attitudes toward information about uncertain punishments and rewards are separable
  • ACC neurons anticipate information about either punishments or rewards
  • vlPFC neurons reflect integrated preferences for both reward and punishment information

Summary

Humans and animals can be strongly motivated to seek information to resolve uncertainty about rewards and punishments. In particular, despite its clinical and societal relevance, very little is known about information seeking about punishments.

We show that attitudes toward information about punishments and rewards are distinct and separable at both behavioral and neuronal levels.

We demonstrate the existence of prefrontal neuronal populations that anticipate opportunities to gain information in a relatively valence-specific manner, separately anticipating information about either punishments or rewards.

These neurons are located in anatomically interconnected subregions of anterior cingulate cortex (ACC) and ventrolateral prefrontal cortex (vlPFC) in area 12o/47. Unlike ACC, vlPFC also contains a population of neurons that integrate attitudes toward both reward and punishment information, to encode the overall preference for information in a bivalent manner.

This cortical network is well suited to mediate information seeking by integrating the desire to resolve uncertainty about multiple, distinct motivational outcomes.



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