New research has found key differences in the brains of patients with obsessive-compulsive disorder who respond to one form of therapy over another.

The findings could improve the odds that people with OCD will receive a therapy that really works for them, something that eludes more than a third of those who currently get OCD treatment, according to researchers at the University of Michigan in Ann Arbor.

The study suggests the possibility of predicting which of two types of therapy will help teens and adults with OCD: one that exposes them to the specific subject of their obsessive thoughts and compulsive behaviors, or one that focuses on general stress reduction and a problem-solving approach.

While the researchers caution that it’s too early for their work to be used by patients and mental health therapists, they note they are conducting further studies that will test the framework and see if it also applies to children with OCD or obsessive tendencies.

Published in the American Journal of Psychiatry, the new study examines advanced brain scans of 87 teens and adults with moderate to severe OCD who were randomly assigned to one of the two types of therapy for 12 weeks.

The researchers found that, in general, both types of therapy reduced the patients’ symptoms.

They also found that the approach known as exposure therapy, a form of cognitive behavioral therapy or CBT, was more effective and reduced symptoms more as time went on, compared with stress-management therapy or SMT.

But when the researchers looked back at the brain scans taken before the patients began therapy, and linked them to individual treatment response, they said they found striking patterns.

The brain scans were taken while patients performed a simple cognitive task and responded to a small monetary reward if they did the task correctly.

Those who started out with more activation in brain circuits for processing cognitive demands and reward during the tests were more likely to respond to CBT. But those who started out with less activation in those same areas during the same tests were more likely to respond well to SMT, the findings suggest.

“We found that the more OCD-specific form of therapy, the one based on exposure to the focus of obsession and compulsion, was better for relieving symptoms, which in itself is a valuable finding from this head-to-head randomized comparison of two treatment options,” said Stephan Taylor, M.D., the study’s senior author and a professor of psychiatry at Michigan Medicine, U-M’s academic medical center.

“But when we looked at the brain to see what was behind that response, we found that the more strength patients had in certain brain areas were linked to a greater chance of responding to exposure-based CBT.”

The brain regions and circuits that had the strongest links to treatment have already been identified as important to OCD and have even been targets for treatment with an emerging therapy called transcranial magnetic stimulation, the researchers noted.

Specifically, stronger activity in the circuit called the cingulo-opercular network during the cognitive task, and stronger activity in the orbitostriato-thalamic network when the reward was at stake, was associated with better response to exposure-based CBT.

Lower activity in both regions was associated with better response to the stress-reduction SMT.

The effects didn’t vary across age groups, the researchers added.

“These findings speak to a mechanism for therapy’s effects, because the brain regions associated with those effects overlap substantially with those implicated previously in this disorder,” said Luke Norman, Ph.D., who led the work as a U-M neuroscience postdoctoral fellow. “This suggests we need to draw upon the most-affected networks during therapy itself, but further research is needed to confirm.”

The brain scans were done while patients underwent a test that required them to pick the correct letter out of a display, and offered a potential monetary reward if they performed the task correctly. This measured both their ability to exert control over their cognitive processes in picking out the right letter, and the extent to which the promise of a reward motivated them, the researchers explained.

One of the areas most linked to CBT treatment response was the rostral anterior cingulate cortex (rACC). Past research has already linked it to OCD and treatment response, and it’s thought to play a key role in self-regulation of response to OCD triggers, the researchers said. Previously, the University of Michigan team had shown that people with OCD tend to have reduced activation in the rACC when asked to perform tasks that involve cognitive control.

Among those who responded best to CBT, the researchers saw stronger pre-treatment activation in areas of the brain associated with learning how to extinguish fear-based responses to something that has caused fear in the past.

Because exposure therapy for OCD involves facing the thing or situation that provokes obsessive and fearful responses, having a stronger ability to be motivated by rewards might help someone stick with therapy despite having to face their triggers, the researchers suggested.

The findings suggest a path to personalizing the choice of therapy not by doing brain scans on everyone with OCD — which would be impractical, according to the researchers— but by using everyday tests that measure the kinds of characteristics that might predict better success with one therapy or the other.

Easily administered behavioral tests could be developed to help therapists recommend CBT to those who have the most cognitive control and reward responsiveness. Likewise, they could suggest SMT to those who would benefit most from being taught to relax and use problem-solving techniques to improve their response to stressors, said Kate Fitzgerald, M.D., a pediatric OCD specialist at Michigan Medicine. Fitzgerald is co-senior author of the paper and leads multiple studies of OCD therapy for children and adolescents.

Computer-based brain-training exercises that can strengthen these tendencies, and rewards for exposing yourself to the thing or action that triggers OCD symptoms, may hold the potential to improve therapy response, she said.

“This kind of research may help inform efforts to do cognitive control training and ramp up the circuits that help patients overcome conflict between obsessive fears and insight that these fears don’t make sense so that patients can dismiss the fear as improbable, rather than trying to make it go away with compulsive behaviors,” she said.

“Our research shows that different brains respond to different treatments, and if we can build on this knowledge we could move toward a more precision-medicine approach for OCD.”

In children and teens, whose brains are still maturing, there’s an especially good chance of helping them improve their brains’ control functions, she said.

Fitzgerald and her research team are recruiting young people with diagnosed OCD, and OCD-like tendencies, for a clinical trial that provides CBT and includes brain scanning before and after therapy.

Since OCD symptoms typically start in the tween years, though diagnosis may not occur until the teen or young adult years, it’s important to study children with sub-clinical symptoms, she noted.

Though the study involves in-person interactions for the brain scans, the CBT exposure therapy is done through video chat. In fact, Fitzgerald says, this can make it easier for children and teens to confront the item or situation that triggers their OCD-like impulses, because these are often found in the home.

“We need families and patients to engage with researchers in studies like these,” she said. “Only through research can we understand what works best for different groups of patients. And perhaps by doing so we can expand the availability of the most evidence-based OCD therapies, including by engaging psychologists and clinical social workers in leading treatment programs, in addition to psychiatrists at specialized centers.”

Source: Michigan Medicine — University of Michigan

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